Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
Reads0
Chats0
TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
Citations
More filters
Journal ArticleDOI
Endothelial cells promote triple-negative breast cancer cell metastasis via PAI-1 and CCL5 signaling.
Wenwen Zhang,Wenwen Zhang,Jing Xu,Hehui Fang,Lin Tang,Weiwei Chen,Qian Sun,Qun Zhang,Fang Yang,Zijia Sun,Lulu Cao,Yucai Wang,Xiaoxiang Guan +12 more
TL;DR: It is demonstrated that ECs—when mixed with TNBC cells—could increase TNBC cell metastatic potency and illustrate the potential of developing new PAI‐1‐ and CCL5‐targeting therapy for patients with T NBC.
Journal ArticleDOI
Translational Significance for Tumor Metastasis of Tumor-Associated Macrophages and Epithelial–Mesenchymal Transition
TL;DR: Clinical and experimental evidence is presented for control of TAMs in promoting cancer cell invasion and migration and their interaction with the EMT process in the metastatic cascade, suggesting that the signaling pathways that interconnect TAMs and EMT-modified cancer cells may represent promising therapeutic targets for the treatment of tumor metastasis.
Journal ArticleDOI
Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells
Min Lu,Lijuan Xia,Yen-Chun Liu,Tsivia Hochman,Laetizia Bizzari,Daniel Aruch,Jane Lew,Rona Singer Weinberg,Judith D. Goldberg,Ronald Hoffman +9 more
TL;DR: Levels of a specific inflammatory cytokine, lipocalin-2 (LCN2), were elevated in the plasmas of patients with myeloproliferative neoplasms and that LCN2 was elaborated by MF myeloid cells, indicating that LCn2 is an additional MFinflammatory cytokine that likely contributes to the creation of a cascade of events that results in not only a predominance of the MF clone but also a dysfunctional microenvironment.
Journal ArticleDOI
Metastasis-promoting role of extravasated platelet activation in tumor.
Tomoharu Miyashita,Hidehiro Tajima,Isamu Makino,Hisatoshi Nakagawara,Hirohisa Kitagawa,Sachio Fushida,John W. Harmon,Tetsuo Ohta +7 more
TL;DR: It is demonstrated that extravasated platelet aggregation is associated with the first step in the formation of the EMT, suggesting a potential role for antiplatelet agents to suppress EMT and metastasis by changing the tumor microenvironment.
Journal ArticleDOI
Engineering a vascularised 3D in vitro model of cancer progression
Tarig Magdeldin,Víctor López-Dávila,Judith Pape,Grant W. W. Cameron,Mark Emberton,Marilena Loizidou,Umber Cheema +6 more
TL;DR: 3D in vitro tumour model exhibits biomimetic attributes that may permit their use in studying microenvironment clues of tumour progression and angiogenesis, and interestingly, the disruption of vascular networks by cancer cells was driven by changes in expression of several anti-angiogenic genes.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.