Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
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Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference
TL;DR: In this paper , a bifunctional antitumor platform was constructed via coordinated interactions between metal ions and nucleotides to synergistically activate ferroptosis and interrupt energy metabolism for tumor therapy.
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Competition and niche construction in a model of cancer metastasis.
Jimmy J. Qian,Erol Akçay +1 more
TL;DR: The results indicate that even if metastatic subclones arise through mutation, metastasis may be hindered by interclonal competition, providing a potential explanation for recent surprising findings that most metastases are derived from early mutants in primary tumors.
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Expression of fibulin-1 predicted good prognosis in patients with colorectal cancer.
TL;DR: High fibulin-1 expression showed longer survival time in colorectal cancer patients, especially in the patients with stage I/II, and may be useful as a diagnosis and prognosis marker for coloreCTal cancer.
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Extracellular Vesicles Orchestrate Immune and Tumor Interaction Networks.
TL;DR: This work provides an insightful and unifying mechanistic understanding of EVs in immunity and tumorigenesis by dissecting the role of EVs within the continuum of immune cell physiology, immune–infection responses, and the immune–tumor microenvironment.
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Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment
TL;DR: A review of the recent studies and challenges of using nanoparticles to target innate immune cells is presented in this article, where the authors examine the immunosuppressive properties of certain immune cells that limit clinical benefits.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.