Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
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Recapitulating Tumorigenesis in vitro: Opportunities and Challenges of 3D Bioprinting.
Gabriela S Kronemberger,Guilherme A S C Miranda,Renata S N Tavares,Bianca Montenegro,Úrsula de A Kopke,Leandra Santos Baptista +5 more
TL;DR: In this article, the authors explore the principal cell components and extracellular matrix composition of solid tumor microenvironment; the recapitulation of tumorigenesis in vitro using spheroids and organoids as 3D culture models; and the opportunities, challenges, and applications of 3D bioprinting in this area.
Journal ArticleDOI
A Systematic Framework for Identifying Prognostic Genes in the Tumor Microenvironment of Colon Cancer
TL;DR: It is demonstrated that stromal and immune scores were significantly associated with colon cancer stages and the prognostic model established with the nine-gene signature was able to effectively predict the outcome of colon cancer patients.
Journal ArticleDOI
DNA nanostructures for stimuli-responsive drug delivery
TL;DR: In this article , the authors systematically reviewed the recent studies on various stimuli-responsive DNA nanostructure based drug delivery systems and classified them according to different types of stimuli, and highlighted the current challenges and prospects regarding this promising field.
Journal ArticleDOI
Human Metaplastic Breast Carcinoma and Decorin.
Pia Boström,Annele Sainio,Natalja Eigėlienė,Anne Jokilammi,Klaus Elenius,Klaus Elenius,Ilkka Koskivuo,Hannu Järveläinen +7 more
TL;DR: The MBC tumour was shown to be completely negative for decorin immunoreactivity demonstrating that the malignant cells were not able to synthesize decorin, and approaches to develop new, decorin-based adjuvant therapies for MBC are supported.
Book ChapterDOI
TGFβ Signaling in the Tumor Microenvironment
TL;DR: An overview of the complex biology of the T GFβ family is presented, and the roles of TGFβ signaling in carcinogenesis is discussed and how this knowledge is being leveraged to develop TGF β inhibition therapies against the tumor is discussed.
References
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Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.