Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
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Journal ArticleDOI
miR-181d-5p-FOXP1 feedback loop modulates the progression of osteosarcoma
TL;DR: It is revealed that miR-181d-5p-FOXP1 feedback loop modulates cell proliferation and metastasis in osteosarcoma.
Book ChapterDOI
Bioactive Natural Products From the Genus Kalanchoe as Cancer Chemopreventive Agents: A Review
TL;DR: The use of some species belonging to genus Kalanchoe could be of interest for the development of chemopreventive studies, thanks to their capacity to biosynthesize several bioactive compounds with cytotoxic and other anticancer-associated properties.
Journal ArticleDOI
Effects of the ruthenium-based drug NAMI-A on the roles played by TGF-β1 in the metastatic process
TL;DR: The effects of NAMI-A on the biological role of TGF-β1 in cancer metastasis are insufficient to attribute the responsibility for the anti-metastatic activity of the ruthenium-based drug to this target alone.
Journal ArticleDOI
Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer.
Jing Jiao,Tomo-o Ishikawa,Darren S. Dumlao,Paul C. Norris,Clara E. Magyar,Carol Mikulec,Art Catapang,Edward A. Dennis,Susan M. Fischer,Harvey R. Herschman +9 more
TL;DR: Cox-2 gene deletion demonstrates that intrinsic COX-2 expression in initiated keratinocytes is a principal driver of skin carcinogenesis; lipidomic analysis identifies likely prostanoid effectors.
Journal ArticleDOI
Next-generation pathology--surveillance of tumor microecology.
Björn Koos,Masood Kamali-Moghaddam,Leonor David,Manuel Sobrinho-Simões,Manuel Sobrinho-Simões,Anna Dimberg,Mats Nilsson,Carolina Wählby,Ola Söderberg +8 more
TL;DR: This view is described on how recent developments in molecular technologies, focusing on proximity ligation assay and padlock probes, can be applied to merge the two branches of pathology, allowing molecular profiling under histologic observation.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.