Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
Citations
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Targeting Tumor Microenvironment for Cancer Therapy.
TL;DR: In this article, a big effort has been made to develop new therapeutic strategies towards a more efficient targeting of tumor microenvironment (TME) components, extending from conventional therapeutics, to combined therapies and nanomedicines; and the development of models that accurately resemble the TME for bench investigations.
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GSH‐Depleted PtCu3 Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy
Xiaoyan Zhong,Xianwen Wang,Liang Cheng,Yong'an Tang,Guiting Zhan,Fei Gong,Rui Zhang,Jun Hu,Zhuang Liu,Xiangliang Yang +9 more
TL;DR: PtCu3 nanocages are first reported as acting as a sonosensitizer with highly efficient ROS generation under ultrasound irradiation, and can act as horseradish peroxidase‐like nanozymes, catalyzing the decomposition of H2O2 into •OH under acidic conditions for CDT.
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Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells.
TL;DR: Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure.
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Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies
TL;DR: Many anticancer polyphenols cause cellular growth arrest through the induction of a ROS-dependent premature senescence and are considered promising antitumour therapeutic tools.
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High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy
Xiangqin Meng,Dandan Li,Lei Chen,Lei Chen,Helen He,Qian Wang,Chaoyi Hong,Jiuyang He,Xingfa Gao,Yili Yang,Bing Jiang,Guohui Nie,Xiyun Yan,Xiyun Yan,Lizeng Gao,Lizeng Gao,Kelong Fan,Kelong Fan +17 more
TL;DR: In this paper, a pyrite peroxidase nanozyme with ultrahigh H2O2 affinity was presented, which achieved a 4144-and 3086-fold increase of catalytic activity compared with that of classical Fe3O4 nanozyme and natural horseradish peroxideidase, respectively.
References
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CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer.
Dingzhi Wang,Haibin Wang,Joanne Brown,Takiko Daikoku,Wei Ning,Qiong Shi,Ann Richmond,Robert M. Strieter,Sudhansu K. Dey,Raymond N. DuBois +9 more
TL;DR: In this paper, the authors found that CXCL1 expression correlates with prostaglandin E2 levels in human colorectal cancer cells, and that PGE2 released from carcinoma cells induces microvascular endothelial cell migration and tube formation in vitro.
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Rho protein crosstalk: another social network?
TL;DR: The main mechanisms of Rho protein crosstalk are described, which can occur at three different levels of the pathway: (i) throughregulation of activity, (ii) through regulation of protein expression and stability, and (iii)through regulation of downstream signaling pathways.
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Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells.
Stefania Cannito,Erica Novo,Alessandra Compagnone,Lorenzo Valfrè di Bonzo,Chiara Busletta,E. Zamara,Claudia Paternostro,Davide Povero,Andrea Bandino,Francesca Bozzo,Carlo Cravanzola,Vittoria Bravoco,Sebastiano Colombatto,Maurizio Parola +13 more
TL;DR: It is indicated that in cancer cells, early redox mechanisms can switch on hypoxia-dependent EMT programme whereas increased invasiveness is sustained by late and HIF-1alpha-dependent release of VEGF.
CXCL1 induced by prostaglandin E 2 promotes angiogenesis in colorectal cancer
Dingzhi Wang,Haibin Wang,Joanne Brown,Takiko Daikoku,Wei Ning,Qiong Shi,Ann Richmond,Robert M. Strieter,Sudhansu K. Dey,Raymond N. DuBois +9 more
TL;DR: PGE2 induces expression of CXCL1 (growth-regulated oncogene α), a pro-angiogenic chemokine, in human CRC cells and promotes tumor growth in vivo by induction of CxCL1 expression, which results in increased tumor microvessel formation.