Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
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Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment
TL;DR: It is suggested that BEC and LEC in various microenvironments can be orchestrators of tumour progression and proposes new mechanism-based strategies to discover new therapies to supplement conventional anti-angiogenic and anti-lymphangiogens therapies.
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CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis.
Bingxue Shang,A Gao,Yanyan Pan,Guangbo Zhang,Jian Tu,Yinghui Zhou,Ping Yang,Zhifei Cao,Q Wei,Y Ding,Jinping Zhang,Yan Zhao,Quansheng Zhou +12 more
TL;DR: Overexpression of CT45A1 in breast cancer cells markedly upregulated various oncogenic and metastatic genes, constitutively activated ERK and CREB signaling pathways, promoted epithelial–mesenchymal transition, and increased cell stemness, tumorigenesis, invasion, and metastasis, whereas silencing CT 45A1 significantly reduced cancer cell migration and invasion.
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Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment.
Ching Ann Liu,Chia Yu Chang,Kuo Wei Hsueh,Hong-Lin Su,Tzyy-Wen Chiou,Shinn Zong Lin,Horng-Jyh Harn +6 more
TL;DR: Therapeutic goals including cancer stem cells, phenotypic shifts, EZH2/AXL/TGF-β axis activation, miRNAs and exosomes are relevant to GBM metastasis to develop novel targeted therapeutics for GBM and other brain cancers.
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Ecology meets cancer biology: The cancer swamp promotes the lethal cancer phenotype
Sarah R. Amend,Kenneth J. Pienta +1 more
TL;DR: As they grow, tumors fundamentally alter their microenvironment, disrupting the homeostasis of the host organ and eventually the patient as a whole, and this “cancer swamp” has genetic and epigenetic effects at the local ecosystem level to promote metastasis and at the systemic host level to induce cytokine-mediated lethal syndromes.
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Imaging and Selective Elimination of Glioblastoma Stem Cells with Theranostic Near-Infrared-Labeled CD133-Specific Antibodies
Hua Jing,Claudia Weidensteiner,Wilfried Reichardt,Simone Gaedicke,Xuekai Zhu,Anca-Ligia Grosu,Hisataka Kobayashi,Gabriele Niedermann +7 more
TL;DR: The highly efficient NIR-PIT of human tumor xenografts initiated from patient-derived cancer stem cells (CSCs) is reported, which may facilitate intraoperative imaging and histopathological evaluation of tumor borders and enable the highly specific and efficient eradication of CSCs.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.