Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
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Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling.
Cassandra Ringuette Goulet,Geneviève Bernard,Sarah Tremblay,Stéphane Chabaud,Stéphane Bolduc,Frédéric Pouliot +5 more
TL;DR: It is demonstrated that bladder cancer cells trigger the differentiation of fibroblasts to CAFs by exosomes-mediated TGFβ transfer and SMAD pathway activation, a new molecular mechanism involved in cancer-associated fibroblast activation.
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Cancer stem cells (CSCs): metabolic strategies for their identification and eradication.
Ernestina Marianna De Francesco,Ernestina Marianna De Francesco,Federica Sotgia,Michael P. Lisanti +3 more
TL;DR: The potential of comprehensive metabolic approaches to identify and selectively eradicate CSCs is described, together with the possibility to ‘force’ C SCs within certain metabolic dependences, in order to effectively target such metabolic biochemical inflexibilities.
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Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling.
Cassandra Ringuette Goulet,Audrey Champagne,Geneviève Bernard,Dominique Vandal,Stéphane Chabaud,Frédéric Pouliot,Stéphane Bolduc +6 more
TL;DR: It is concluded that CAFs promote aggressive phenotypes of non-invasive bladder cancer cells through an EMT induced by the secretion of IL-6, and that IL6 expression is up-regulated in aggressive bladder cancer and correlate with CAF marker ACTA2.
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Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression
TL;DR: The mutual collaboration of TGF-β and ROS in tumorigenesis is highly complex, and, due to their differential roles in tumor progression, careful consideration should be taken when thinking of combinatorial targeting in cancer therapies.
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Bone tissue remodeling and development: focus on matrix metalloproteinase functions.
TL;DR: The principal properties of MMPs and their inhibitors (TIMPs and RECK) are looked at, an up-date on their known functions in bone development and remodeling and their potential application to Bone Bioengineering are discussed.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.