Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
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Role of Immune Microenvironmental Factors for Improving the IPI-related Risk Stratification of Aggressive B Cell Lymphoma.
TL;DR: A convenient and inexpensive tool for use in risk stratification of aggressive B cell lymphomas is developed, although further studies on the role of immune microenvironmental factors are needed.
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LRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis.
Océane Campion,Océane Campion,Jessica Thevenard Devy,Jessica Thevenard Devy,Clotilde Billottet,Christophe Schneider,Christophe Schneider,Nicolas Etique,Nicolas Etique,Jean-William Dupuy,Anne-Aurélie Raymond,Camille Boulagnon Rombi,Marie Meunier,Marie Meunier,El-Hadi Djermoune,Elodie Lelièvre,Elodie Lelièvre,Amandine Wahart,Amandine Wahart,Camille Bour,Camille Bour,Cathy Hachet,Cathy Hachet,Stefano Cairo,Andreas Bikfalvi,Stéphane Dedieu,Stéphane Dedieu,Jérôme Devy,Jérôme Devy +28 more
TL;DR: In this paper, a proteomics analysis revealed that LRP-1 supports tumor growth and angiogenesis by regulating TGF-β signaling and plasminogen/plasmin system.
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New insights into cancer's exploitation of platelets.
TL;DR: In a recent paper published in the Journal of Clinical Investigation, Lucotti et al used a combination of in vitro and in vivo experimental systems to provide strong evidence directly linking activation of the cyclooxygenase/thromboxane A2 (COX‐1/TXA2) pathway in platelets to metastatic potential.
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Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy
TL;DR:
Genomics based biomarker discovery in oral squamous cell carcinoma
TL;DR: The present thesis showed signaling mechanisms and pathways essential for oral cancer progression through genomics approach and identified markers that are of diagnostic, prognostic and therapeutic importance.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.