Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes.
TLDR
This review gives a short insight into the functional formation of these cytokine receptors and discusses both the binding kinetics of ligand/receptor interactions and the expression of the receptor chains for these cytokines in various cell types; both of which are crucial factors in explaining the efficiency by whichThese cytokines induce intracellular signaling and gene expression.Abstract:
Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic inflammation. They play important roles in regulating the responses of lymphocytes, myeloid cells, and non-hematopoietic cells. In T-cells, IL-4 induces the differentiation of naive CD4 T cells into Th2 cells, in B cells, IL-4 drives the immunoglobulin (Ig) class switch to IgG1 and IgE, and in macrophages, IL-4 and IL-13 induce alternative macrophage activation. This review gives a short insight into the functional formation of these cytokine receptors. I will discuss both the binding kinetics of ligand/receptor interactions and the expression of the receptor chains for these cytokines in various cell types; both of which are crucial factors in explaining the efficiency by which these cytokines induce intracellular signaling and gene expression. Work initiated in part by William (Bill) E. Paul on IL-4 some 30 years ago has now grown into a major building block of our current understanding of basic immunology and the immune response. This knowledge on IL-4 has growing clinical importance, as therapeutic approaches targeting the cytokine and its signal transduction are becoming a part of the clinical practice in treating allergic diseases. Just by reading the reference list of this short review, one can appreciate the enormous input Bill has had on shaping our understanding of the pathophysiology of allergic inflammation and in particular the role of IL-4 in this process.read more
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Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
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The Human and Mouse Enteric Nervous System at Single-Cell Resolution.
Eugene Drokhlyansky,Christopher Smillie,Nicholas Van Wittenberghe,Maria Ericsson,Gabriel K. Griffin,Gabriel K. Griffin,Gökcen Eraslan,Danielle Dionne,Michael S. Cuoco,Max N. Goder-Reiser,Tatyana Sharova,Olena Kuksenko,Andrew J. Aguirre,Andrew J. Aguirre,Genevieve M. Boland,Daniel B. Graham,Daniel B. Graham,Orit Rozenblatt-Rosen,Ramnik J. Xavier,Aviv Regev,Aviv Regev +20 more
TL;DR: Two methods to profile the ENS of adult mice and humans at single-cell resolution are developed: RAISIN RNA-seq for profiling intact nuclei with ribosome-bound mRNA and MIRACL- sequencing for label-free enrichment of rare cell types by droplet-based profiling.
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FinnGen: Unique genetic insights from combining isolated population and national health register data
Mitja I. Kurki,Juha Karjalainen,Priit Palta,T. P. Sipilampauml,Kati Kristiansson,Kati Donner,Mary Pat Reeve,Hannele Laivuori,Mervi Aavikko,Mari A. Kaunisto,Anu Loukola,Elisa Lahtela,Hannele Mattsson,Päivi Laiho,P. della Briotta Parolo,Arto Lehisto,Masahiro Kanai,Nina Mars,J. RaÌmoÌ,Tuomo Kiiskinen,Henrike O. Heyne,Kumar Veerapen,S. RuÌeger,S. LemmelaÌ,W. Zhou,Sanni Ruotsalainen,K. PaÌrn,Tero Hiekkalinna,Sami Koskelainen,Tuula A. Paajanen,Victor Llorens,Javier Gracia-Tabuenca,Harri Siirtola,Katherine Reis,Adel Elnahas,K. Aalto-SetaÌlaÌ,Kaur Alasoo,Muhammed Ikbal Arvas,Kirsi Auro,Shrayashi Biswas,A. Bizaki-Vallaskangas +40 more
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Interleukin-13: Targeting an underestimated cytokine in atopic dermatitis.
TL;DR: An update on the role of IL‐13 in AD is provided and the different strategies aimed at interfering with its biologic activity as well as their potential in a precision medicine approach in the management of AD are discussed.
Posted ContentDOI
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
Fatai S. Oladunni,Jun-Gyu Park,Paula Pino Tamayo,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Deepak Kaushal,Luis D. Giavedoni,Xavier Alvarez,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: K18 hACE2-transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS/COVID-19 disease.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
Journal ArticleDOI
Innate production of T H 2 cytokines by adipose tissue-associated c-Kit + Sca-1 + lymphoid cells
Kazuyo Moro,Taketo Yamada,Masanobu Tanabe,Tsutomu Takeuchi,Tomokatsu Ikawa,Hiroshi Kawamoto,Jun Ichi Furusawa,Masashi Ohtani,Hideki Fujii,Shigeo Koyasu +9 more
TL;DR: In this article, a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity was reported. But these cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R.
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