Open Access
Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission
Alejandro Dorenbaum,Coleen K. Cunningham,Richard D. Gelber,Mary Culnane,Lynne M. Mofenson,Paula Britto,Marie-Louise Newell,Jean François Delfraissy,Bethann Cunningham-Schrader,John L. Sullivan +9 more
TLDR
Risk of perinatal HIV transmission was low and no benefit from additional intrapartum/newborn nevirapine was demonstrated when women received prenatal care and antenatal ART, and elective cesarean section was made available.About:
The article was published on 2017-01-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Nevirapine.read more
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Journal ArticleDOI
Approaches for scaling up human immunodeficiency virus testing and counseling in prevention of mother-to-child human immunodeficiency virus transmission settings in resource-limited countries
Omotayo Bolu,Virginia Allread,Tracy Creek,Elizabeth M. Stringer,Fatu Forna,Marc Bulterys,Nathan Shaffer +6 more
TL;DR: In this paper, the authors review best practices needed for expansion of testing and counseling in PMTCT settings in resource-limited countries, including a policy of provider-initiated testing with right to refuse (opt-out); group pretest counseling; rapid HIV testing; innovative staffing strategies; and community and male involvement.
Journal ArticleDOI
A Framework for Elimination of Perinatal Transmission of HIV in the United States
Steven R. Nesheim,Allan W. Taylor,Margaret A. Lampe,Peter H. Kilmarx,Lauren F. Fitz Harris,Suzanne K. Whitmore,Judy Griffith,Melissa Thomas-Proctor,Kevin A. Fenton,Jonathan Mermin +9 more
TL;DR: Elimination of mother-to-child HIV transmission will not be a one-time accomplishment but, rather, will require sustained effort as long as there are new HIV infections in women of childbearing age.
Journal Article
Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. Update 2011.
Andrea Antinori,Simone Marcotullio,Adriana Ammassari,Massimo Andreoni,G. Angarano,G. Carosi,Paola Cinque,d'Arminio Monforte A,Di Perri G,Barbara Ensoli,Enrico Ferrazzi,Massimo Galli,Claudio Maria Mastroianni,Alberto Matteelli,Francesco Mazzotta,Mauro Moroni,Giorgio Palù,M. Puoti,Puro,Giuliano Rizzardini,Evangelista Sagnelli,Fredy Suter,Stefano Vella,Adriano Lazzarin +23 more
TL;DR: New recommendations were released concerning the following topics: estimate of the HIV continuum of care in Italy, optimal timing and preferred drug combinations for starting antiretroviral therapy, treatment optimization, and pre-exposure prophilaxis (PrEP).
Journal ArticleDOI
Maternal hepatotoxicity with nevirapine as part of combination antiretroviral therapy in pregnancy
F Lyons,Susan Hopkins,B Kelleher,A McGeary,Gerard Sheehan,J Geoghegan,Colm Bergin,Fiona Mulcahy,PA McCormick +8 more
TL;DR: To describe the maternal tolerability of nevirapine as part of combination antiretroviral therapy in pregnancy at three HIV centres in Dublin, Ireland and to determine risk factors for development of significant hepatotoxicity.
Journal ArticleDOI
Systematic review of the efficacy of antiretroviral therapies for reducing the risk of mother-to-child transmission of HIV infection.
TL;DR: Evaluation of the efficacy of antiretroviral therapies in reducing the risk of mother‐to‐child transmission of HIV infection in women and children in Northern Ireland finds them to be safe and effective.
References
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Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
TL;DR: Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
Journal ArticleDOI
Treatment for adult HIV infection : 2006 recommendations of the international AIDS society-USA panel
Scott M. Hammer,Michael S. Saag,Mauro Schechter,Julio S. G. Montaner,Robert T. Schooley,Donna M. Jacobsen,Melanie A. Thompson,Charles C. J. Carpenter,Margaret A. Fischl,Brian Gazzard,Jose M. Gatell,Martin S. Hirsch,David Katzenstein +12 more
TL;DR: The virologic target for patients with treatment failure is now a plasma HIV-1 RNA level below 50 copies/mL, making delivery of state-of-the-art care challenging.
Journal ArticleDOI
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).
Susan H. Eshleman,Martin Mracna,Laura Guay,Martina Deseyve,Shawn Cunningham,Mark Mirochnick,Philippa Musoke,Thomas Fleming,Mary Glenn Fowler,Lynne M. Mofenson,Francis Mmiro,J. Brooks Jackson +11 more
TL;DR: NVPR was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVPR mutations were detected in women versus infants, and NVP-resistant HIV-1 faded from detection in women and infants over time.
Journal ArticleDOI
Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
Laurent Mandelbrot,Aline Landreau-Mascaro,Claire Rekacewicz,Alain Berrebi,Jean Louis Bénifla,Marianne Burgard,Eric Lachassine,Béatrice Barret,Marie-Laure Chaix,André Bongain,Nicole Ciraru-Vigneron,Catherine Crenn-Hebert,Jean-François Delfraissy,Christine Rouzioux,Marie-Jeanne Mayaux,Stéphane Blanche +15 more
TL;DR: Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.
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