Open Access
Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission
Alejandro Dorenbaum,Coleen K. Cunningham,Richard D. Gelber,Mary Culnane,Lynne M. Mofenson,Paula Britto,Marie-Louise Newell,Jean François Delfraissy,Bethann Cunningham-Schrader,John L. Sullivan +9 more
TLDR
Risk of perinatal HIV transmission was low and no benefit from additional intrapartum/newborn nevirapine was demonstrated when women received prenatal care and antenatal ART, and elective cesarean section was made available.About:
The article was published on 2017-01-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Nevirapine.read more
Citations
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Book ChapterDOI
Prevention of Sexually Transmitted HIV Infection
Jose G. Castro,Maria L. Alcaide +1 more
Journal ArticleDOI
Early ART initiation among HIV-positive pregnant women in central Mozambique: a stepped wedge randomized controlled trial of an optimized Option B+ approach.
James Cowan,James Cowan,Mark A. Micek,Jessica Greenberg Cowan,Jessica Greenberg Cowan,Manuel Napúa,Roxanne Hoek,Sarah Gimbel,Sarah Gimbel,Stephen Gloyd,Stephen Gloyd,Kenneth Sherr,Kenneth Sherr,James Pfeiffer,James Pfeiffer,Rachel R. Chapman,Rachel R. Chapman +16 more
TL;DR: The overall objective of this trial is to develop and test a pilot intervention in central Mozambique to implement the new Option B+ guidelines with high fidelity and increase the proportion of HIV-positive pregnant women in target antenatal clinics who start ART prior to delivery and are retained in care.
Journal ArticleDOI
Italian consensus statement on paediatric HIV infection.
Carlo Giaquinto,Martina Penazzato,Raffaella Rosso,Stefania Bernardi,Osvalda Rampon,Paola Nasta,Adriana Ammassari,Andrea Antinori,Raffaele Badolato,G. Castelli Gattinara,A d'Arminio Monforte,M. De Martino,A. De Rossi,P. Di Gregorio,Susanna Esposito,F. Fatuzzo,Simona Fiore,A. Franco,Clara Gabiano,Luisa Galli,Orazio Genovese,Vania Giacomet,Antonietta Giannattasio,C. Gotta,Alfredo Guarino,Angela Di Martino,Francesco Mazzotta,Nicola Principi,Mario Regazzi,Paolo Rossi,R. Russo,M. Saitta,Filippo Salvini,S. Trotta,Alessandra Viganò,Gian Vincenzo Zuccotti,G. Carosi +36 more
TL;DR: The objective of this document is to identify and reinforce current recommendations concerning the management of HIV infection in infants and children in the context of good resource availability.
Journal ArticleDOI
Preventing mother-to-child transmission of HIV in resource-limited settings
TL;DR: Reducing postnatal transmission of HIV in resource-poor settings through breastfeeding, whilst maintaining child survival, is an urgent priority, given that breastfeeding causes one-third to one-half of all infant HIV infections.
Dissertation
The impact of antiretroviral therapy used in pregnancy on the health of HIV-positive women
TL;DR: The findings presented in this thesis contribute to the evidence-base for the management of pregnant women living with HIV and highlight the need for close monitoring of toxicity in pregnancy and additional drug adherence support following pregnancy.
References
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Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
TL;DR: Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
Journal ArticleDOI
Treatment for adult HIV infection : 2006 recommendations of the international AIDS society-USA panel
Scott M. Hammer,Michael S. Saag,Mauro Schechter,Julio S. G. Montaner,Robert T. Schooley,Donna M. Jacobsen,Melanie A. Thompson,Charles C. J. Carpenter,Margaret A. Fischl,Brian Gazzard,Jose M. Gatell,Martin S. Hirsch,David Katzenstein +12 more
TL;DR: The virologic target for patients with treatment failure is now a plasma HIV-1 RNA level below 50 copies/mL, making delivery of state-of-the-art care challenging.
Journal ArticleDOI
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).
Susan H. Eshleman,Martin Mracna,Laura Guay,Martina Deseyve,Shawn Cunningham,Mark Mirochnick,Philippa Musoke,Thomas Fleming,Mary Glenn Fowler,Lynne M. Mofenson,Francis Mmiro,J. Brooks Jackson +11 more
TL;DR: NVPR was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVPR mutations were detected in women versus infants, and NVP-resistant HIV-1 faded from detection in women and infants over time.
Journal ArticleDOI
Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
Laurent Mandelbrot,Aline Landreau-Mascaro,Claire Rekacewicz,Alain Berrebi,Jean Louis Bénifla,Marianne Burgard,Eric Lachassine,Béatrice Barret,Marie-Laure Chaix,André Bongain,Nicole Ciraru-Vigneron,Catherine Crenn-Hebert,Jean-François Delfraissy,Christine Rouzioux,Marie-Jeanne Mayaux,Stéphane Blanche +15 more
TL;DR: Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.
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