Open Access
Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission
Alejandro Dorenbaum,Coleen K. Cunningham,Richard D. Gelber,Mary Culnane,Lynne M. Mofenson,Paula Britto,Marie-Louise Newell,Jean François Delfraissy,Bethann Cunningham-Schrader,John L. Sullivan +9 more
TLDR
Risk of perinatal HIV transmission was low and no benefit from additional intrapartum/newborn nevirapine was demonstrated when women received prenatal care and antenatal ART, and elective cesarean section was made available.About:
The article was published on 2017-01-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Nevirapine.read more
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Journal Article
Comparison of mother-to-child transmission rates in Ugandan women with subtype A versus D HIV-1 who received single-dose nevirapine prophylaxis: HIV Network For Prevention Trials 012.
Susan H. Eshleman,Laura Guay,Anthony Mwatha,Elizabeth R. Brown,Philippa Musoke,Francis Mmiro,J. Brooks Jackson +6 more
TL;DR: No significant difference was observed in the rate of mother-to-child transmission (MTCT) in women with subtype A versus D HIV-1 who received single-dose nevirapine (NVP), however, there was a trend toward a higher rate of MTCT among women withSubtype D, however, which was also apparent among women whose infants were infected after 8 weeks of age.
Journal ArticleDOI
ART outcome in HIV-infected patients
Yannick Manigart,Serge Rozenberg,Patricia Barlow,Michèle Gerard,Evelyne Bertrand,Annick Delvigne +5 more
TL;DR: In couples affected by HIV, an acceptable pregnancy rate was obtained and the worst results were obtained when both partners were infected, especially among HIV-infected couples.
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Prevention of vertical transmission of HIV-1 in resource-limited settings
TL;DR: Although transmission rates in some settings have been reduced to approximately 1%, scale-up and widespread implementation and application of strategic interventions for prevention of mother-to-child transmission of HIV during pregnancy, delivery and breastfeeding are needed in the developing world.
Journal ArticleDOI
Desire for Pregnancy and Risk Behavior in Young HIV-Positive Women
TL;DR: DFP was associated with sexual behaviors that may place young women at risk for STI acquisition and secondary HIV transmission to partners and should be assessed in routine HIV care, providing education about fertility options, interventions for vertical transmission, family planning, and risk reduction counseling.
Journal ArticleDOI
Extended antenatal antiretroviral use correlates with improved infant outcomes throughout the first year of life.
Maria Cristina Marazzi,Giuseppe Liotta,Karin Nielsen-Saines,J Haswell,Nurja A. Magid,Ersilia Buonomo,Paola Scarcella,Anna Maria Doro Altan,Sandro Mancinelli,Leonardo Palombi +9 more
TL;DR: Extended antenatal ART is protective against adverse infant outcomes up to 12 months of age even in children born to mothers with higher CD4 cell counts.
References
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Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
TL;DR: Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
Journal ArticleDOI
Treatment for adult HIV infection : 2006 recommendations of the international AIDS society-USA panel
Scott M. Hammer,Michael S. Saag,Mauro Schechter,Julio S. G. Montaner,Robert T. Schooley,Donna M. Jacobsen,Melanie A. Thompson,Charles C. J. Carpenter,Margaret A. Fischl,Brian Gazzard,Jose M. Gatell,Martin S. Hirsch,David Katzenstein +12 more
TL;DR: The virologic target for patients with treatment failure is now a plasma HIV-1 RNA level below 50 copies/mL, making delivery of state-of-the-art care challenging.
Journal ArticleDOI
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).
Susan H. Eshleman,Martin Mracna,Laura Guay,Martina Deseyve,Shawn Cunningham,Mark Mirochnick,Philippa Musoke,Thomas Fleming,Mary Glenn Fowler,Lynne M. Mofenson,Francis Mmiro,J. Brooks Jackson +11 more
TL;DR: NVPR was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVPR mutations were detected in women versus infants, and NVP-resistant HIV-1 faded from detection in women and infants over time.
Journal ArticleDOI
Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
Laurent Mandelbrot,Aline Landreau-Mascaro,Claire Rekacewicz,Alain Berrebi,Jean Louis Bénifla,Marianne Burgard,Eric Lachassine,Béatrice Barret,Marie-Laure Chaix,André Bongain,Nicole Ciraru-Vigneron,Catherine Crenn-Hebert,Jean-François Delfraissy,Christine Rouzioux,Marie-Jeanne Mayaux,Stéphane Blanche +15 more
TL;DR: Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.
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