Open Access
Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission
Alejandro Dorenbaum,Coleen K. Cunningham,Richard D. Gelber,Mary Culnane,Lynne M. Mofenson,Paula Britto,Marie-Louise Newell,Jean François Delfraissy,Bethann Cunningham-Schrader,John L. Sullivan +9 more
TLDR
Risk of perinatal HIV transmission was low and no benefit from additional intrapartum/newborn nevirapine was demonstrated when women received prenatal care and antenatal ART, and elective cesarean section was made available.About:
The article was published on 2017-01-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Nevirapine.read more
Citations
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Journal ArticleDOI
Mother to child transmission of HIV infection in the era of highly active antiretroviral therapy
TL;DR: The results suggest that offering an elective Caesarean section delivery to all HIV-infected women, even in areas where HAART is available, is appropriate clinical management, especially for persons with detectable viral loads.
Journal ArticleDOI
Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand.
Marc Lallemant,Gonzague Jourdain,Sophie Le Coeur,Jean Yves Mary,Nicole Ngo-Giang-Huong,Suporn Koetsawang,Siripon Kanshana,Kenneth McIntosh,Vallop Thaineua +8 more
TL;DR: A single dose of nevirapine to the mother, with or without a dose ofNevirapin to the infant, added to oral zidovudine prophylaxis starting at 28 weeks' gestation, is highly effective in reducing mother-to-child transmission of HIV.
Journal ArticleDOI
Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection
Peter Brocklehurst,J Volmink +1 more
TL;DR: To assess which antiretroviral therapies may be effective in decreasing the risk of mother-to-child transmission of HIV infection as well as their effect on neonatal and maternal mortality and morbidity, the Cochrane Controlled Trials Register and conference abstracts were searched.
Journal ArticleDOI
Mother-to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort.
Josiane Warszawski,Roland Tubiana,Jérôme Le Chenadec,Stéphane Blanche,Jean-Paul Teglas,Catherine Dollfus,Albert Faye,Marianne Burgard,Christine Rouzioux,Laurent Mandelbrot,Anrs French Perinatal Cohort +10 more
TL;DR: Low maternal plasma viral load is the key factor for preventing mother-to-child HIV-1 transmission from mothers receiving antenatal antiretroviral therapy, and benefits in terms of MTCT reduction may be expected from early antireTroviral prophylaxis.
Journal ArticleDOI
Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials.
Six Week Extended-Dose Nevirapine (Swen) Study Team,Abubaker Bedri,Berhanu Gudetta,Abdulhamid Isehak,Solomon Kumbi,Sileshi Lulseged,Yohannes Mengistu,Arvind V. Bhore,Ramesh Bhosale,Venkat Varadhrajan,Nikhil Gupte,Jayagowri Sastry,Nishi Suryavanshi,Srikanth Tripathy,Francis Mmiro,Michael Mubiru,Carolyne Onyango,Adrian Taylor,Philippa Musoke,Clemensia Nakabiito,Aida Abashawl,Rahel Adamu,Gretchen Antelman,Robert C. Bollinger,Patricia Bright,Mohammad A Chaudhary,Jacqueline S. Coberly,Laura Guay,Mary Glenn Fowler,Amita Gupta,Elham Hassen,J. Brooks Jackson,Lawrence H. Moulton,Uma Nayak,Saad B. Omer,Lidia Propper,Malathi Ram,Vivian Rexroad,Andrea Ruff,Anita V. Shankar,Sheryl Zwerski +40 more
TL;DR: It is suggested that a longer course of daily infant nevirapine to prevent HIV transmission via breast milk might be more effective where access to affordable and safe replacement feeding is not yet available and where the risks of replacement feeding are high.
References
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Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
TL;DR: Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
Journal ArticleDOI
Treatment for adult HIV infection : 2006 recommendations of the international AIDS society-USA panel
Scott M. Hammer,Michael S. Saag,Mauro Schechter,Julio S. G. Montaner,Robert T. Schooley,Donna M. Jacobsen,Melanie A. Thompson,Charles C. J. Carpenter,Margaret A. Fischl,Brian Gazzard,Jose M. Gatell,Martin S. Hirsch,David Katzenstein +12 more
TL;DR: The virologic target for patients with treatment failure is now a plasma HIV-1 RNA level below 50 copies/mL, making delivery of state-of-the-art care challenging.
Journal ArticleDOI
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).
Susan H. Eshleman,Martin Mracna,Laura Guay,Martina Deseyve,Shawn Cunningham,Mark Mirochnick,Philippa Musoke,Thomas Fleming,Mary Glenn Fowler,Lynne M. Mofenson,Francis Mmiro,J. Brooks Jackson +11 more
TL;DR: NVPR was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVPR mutations were detected in women versus infants, and NVP-resistant HIV-1 faded from detection in women and infants over time.
Journal ArticleDOI
Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
Laurent Mandelbrot,Aline Landreau-Mascaro,Claire Rekacewicz,Alain Berrebi,Jean Louis Bénifla,Marianne Burgard,Eric Lachassine,Béatrice Barret,Marie-Laure Chaix,André Bongain,Nicole Ciraru-Vigneron,Catherine Crenn-Hebert,Jean-François Delfraissy,Christine Rouzioux,Marie-Jeanne Mayaux,Stéphane Blanche +15 more
TL;DR: Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.
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