Open Access
Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission
Alejandro Dorenbaum,Coleen K. Cunningham,Richard D. Gelber,Mary Culnane,Lynne M. Mofenson,Paula Britto,Marie-Louise Newell,Jean François Delfraissy,Bethann Cunningham-Schrader,John L. Sullivan +9 more
TLDR
Risk of perinatal HIV transmission was low and no benefit from additional intrapartum/newborn nevirapine was demonstrated when women received prenatal care and antenatal ART, and elective cesarean section was made available.About:
The article was published on 2017-01-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Nevirapine.read more
Citations
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Twelve-month follow-up of Six Week Extended Dose Nevirapine randomized controlled trials: differential impact of extended-dose nevirapine on mother-to-child transmission and infant death by maternal CD4 cell count.
TL;DR: For populations with limited access to HAART, the results provide evidence for the use of extended-dose regimens to prevent infant deaths and increase HIV-free survival in infants of HIV-infected breastfeeding women, particularly for infants of women with CD4 cell counts more than 350 cells/μl.
Journal ArticleDOI
Future desire for children among women living with HIV in Atlanta, Georgia.
Lisa B. Haddad,Leah Kathleen Machen,Sarah Cordes,Brian Huylebroeck,Augustina Delaney,Igho Ofotokun,Minh Ly Nguyen,Denise J. Jamieson +7 more
TL;DR: Concerns for horizontal and vertical HIV transmission were deterrents to future childbearing and Misinformation regarding HIV transmission risks persists and is a notable concern influencing desire for children.
Journal ArticleDOI
Progress in the prevention of mother to child transmission of HIV in three regions of Tanzania: a retrospective analysis.
Ann M. Buchanan,Dorothy E. Dow,Charles Massambu,Balthazar M. Nyombi,Aisa M Shayo,Rahma Musoke,Sheng Feng,John Bartlett,Coleen K. Cunningham,Werner Schimana +9 more
TL;DR: Significant reductions in MTCT of HIV-1 in three regions of Tanzania coincident with increased use of more effective PMTCT interventions are demonstrated.
Journal ArticleDOI
A cluster randomized controlled trial of lay health worker support for prevention of mother to child transmission of HIV (PMTCT) in South Africa.
Karl Peltzer,Karl Peltzer,Stephen M. Weiss,Manasi Soni,Tae Kyoung Lee,Violeta J. Rodriguez,Violeta J. Rodriguez,Ryan Cook,Ryan Cook,Maria L. Alcaide,Geoffrey Setswe,Geoffrey Setswe,Deborah L. Jones +12 more
TL;DR: The enhanced intervention administered by trained lay health workers did not have any salutary impact on HIV infant status, ART adherence, HIV and PMTCT knowledge.
HIV Transmission Through Breastfeeding
Paolo G. Miotti,Taha E. T. Taha,Newton Kumwenda,Robert Broadhead,Len van der Hoeven,John D. Chiphangwi,Robert J. Biggar +6 more
TL;DR: The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization or the United Nations Children's Fund in preference to others of a similar nature that are not mentioned.
References
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Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
TL;DR: Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
Journal ArticleDOI
Treatment for adult HIV infection : 2006 recommendations of the international AIDS society-USA panel
Scott M. Hammer,Michael S. Saag,Mauro Schechter,Julio S. G. Montaner,Robert T. Schooley,Donna M. Jacobsen,Melanie A. Thompson,Charles C. J. Carpenter,Margaret A. Fischl,Brian Gazzard,Jose M. Gatell,Martin S. Hirsch,David Katzenstein +12 more
TL;DR: The virologic target for patients with treatment failure is now a plasma HIV-1 RNA level below 50 copies/mL, making delivery of state-of-the-art care challenging.
Journal ArticleDOI
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).
Susan H. Eshleman,Martin Mracna,Laura Guay,Martina Deseyve,Shawn Cunningham,Mark Mirochnick,Philippa Musoke,Thomas Fleming,Mary Glenn Fowler,Lynne M. Mofenson,Francis Mmiro,J. Brooks Jackson +11 more
TL;DR: NVPR was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVPR mutations were detected in women versus infants, and NVP-resistant HIV-1 faded from detection in women and infants over time.
Journal ArticleDOI
Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
Laurent Mandelbrot,Aline Landreau-Mascaro,Claire Rekacewicz,Alain Berrebi,Jean Louis Bénifla,Marianne Burgard,Eric Lachassine,Béatrice Barret,Marie-Laure Chaix,André Bongain,Nicole Ciraru-Vigneron,Catherine Crenn-Hebert,Jean-François Delfraissy,Christine Rouzioux,Marie-Jeanne Mayaux,Stéphane Blanche +15 more
TL;DR: Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.
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