Open Access
Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission
Alejandro Dorenbaum,Coleen K. Cunningham,Richard D. Gelber,Mary Culnane,Lynne M. Mofenson,Paula Britto,Marie-Louise Newell,Jean François Delfraissy,Bethann Cunningham-Schrader,John L. Sullivan +9 more
TLDR
Risk of perinatal HIV transmission was low and no benefit from additional intrapartum/newborn nevirapine was demonstrated when women received prenatal care and antenatal ART, and elective cesarean section was made available.About:
The article was published on 2017-01-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Nevirapine.read more
Citations
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Journal ArticleDOI
Cost-effectiveness of nevirapine to prevent mother-to-child HIV transmission in eight African countries.
TL;DR: Small reductions in maternal HIV prevalence or unintended pregnancy by HIV-infected women have equivalent impacts on infant HIV incidence and should be part of an overall strategy to lessen numbers of infant infections.
Journal ArticleDOI
Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022.
Jane Hitti,Lisa M. Frenkel,Alice Stek,Sharon Nachman,David Baker,Adolfo Gonzalez-Garcia,Arthur Provisor,Edwin M. Thorpe,Mary E. Paul,Marc Foca,Jorge Gandia,Sharon Huang,Lee-Jen Wei,Laura M. Stevens,D. Heather Watts,James McNamara +15 more
TL;DR: Continuous nevirapine may be associated with increased toxicity among HIV-1-infected pregnant women with CD4 cell counts greater than 250 cells/μL, as has been observed in non-pregnant women.
Journal ArticleDOI
Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316.
Coleen K. Cunningham,Marie-Laure Chaix,Claire Rekacewicz,Paula Britto,Christine Rouzioux,Richard D. Gelber,Alejandro Dorenbaum,Jean François Delfraissy,Brigitte Bazin,Lynne M. Mofenson,John L. Sullivan +10 more
TL;DR: The risk of nevirapine resistance should be considered when determining the risks or benefits of intrapartum ne virapine in women receiving antepartum antiretroviral therapy.
Journal ArticleDOI
Effects of Highly Active Antiretroviral Therapy Duration and Regimen on Risk for Mother-to-Child Transmission of HIV in Johannesburg, South Africa
Risa M Hoffman,Vivian Black,Karl Technau,Karin van der Merwe,Judith S. Currier,Ashraf Coovadia,Matthew Chersich +6 more
TL;DR: Late initiation of HAART is associated with increased risk of mother-to-child transmission of HIV among women in Africa who start treatment for advanced immunosuppression, and strategies are needed to facilitate earlier identification of HIV-infected women.
Journal ArticleDOI
Pharmacokinetics of Antiretrovirals in Pregnant Women
TL;DR: Pregnancy does not appear to have a significant effect on the pharmacokinetics of the non-nucleoside reverse transcriptase inhibitor nevirapine and there are no data describing the pharmacodynamics of the other non- nucleosid reverse transcript enzyme inhibitors during pregnancy.
References
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Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
TL;DR: Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
Journal ArticleDOI
Treatment for adult HIV infection : 2006 recommendations of the international AIDS society-USA panel
Scott M. Hammer,Michael S. Saag,Mauro Schechter,Julio S. G. Montaner,Robert T. Schooley,Donna M. Jacobsen,Melanie A. Thompson,Charles C. J. Carpenter,Margaret A. Fischl,Brian Gazzard,Jose M. Gatell,Martin S. Hirsch,David Katzenstein +12 more
TL;DR: The virologic target for patients with treatment failure is now a plasma HIV-1 RNA level below 50 copies/mL, making delivery of state-of-the-art care challenging.
Journal ArticleDOI
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).
Susan H. Eshleman,Martin Mracna,Laura Guay,Martina Deseyve,Shawn Cunningham,Mark Mirochnick,Philippa Musoke,Thomas Fleming,Mary Glenn Fowler,Lynne M. Mofenson,Francis Mmiro,J. Brooks Jackson +11 more
TL;DR: NVPR was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVPR mutations were detected in women versus infants, and NVP-resistant HIV-1 faded from detection in women and infants over time.
Journal ArticleDOI
Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
Laurent Mandelbrot,Aline Landreau-Mascaro,Claire Rekacewicz,Alain Berrebi,Jean Louis Bénifla,Marianne Burgard,Eric Lachassine,Béatrice Barret,Marie-Laure Chaix,André Bongain,Nicole Ciraru-Vigneron,Catherine Crenn-Hebert,Jean-François Delfraissy,Christine Rouzioux,Marie-Jeanne Mayaux,Stéphane Blanche +15 more
TL;DR: Lamivudine-zidovudine prophylaxis therapy may be effective in preventing maternal-infant HIV transmission, however, severe adverse effects and emergence of resistance to lamivUDine occurred.
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