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Bruce S. McEwen

Researcher at Rockefeller University

Publications -  1168
Citations -  214913

Bruce S. McEwen is an academic researcher from Rockefeller University. The author has contributed to research in topics: Hippocampus & Hippocampal formation. The author has an hindex of 215, co-authored 1163 publications receiving 200638 citations. Previous affiliations of Bruce S. McEwen include Yale University & National Institutes of Health.

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Journal ArticleDOI

Glucocorticoid Receptor mRNA Expression in the Hippocampal Formation of Male Rats before and after Pubertal Development in Response to Acute or Repeated Stress

TL;DR: Despite the dramatic differences in corticosterone concentration following stress at these two developmental stages, the stress-induced changes in GR expression in the hippocampus before and after pubertal maturation were more similar than different, pointing to a dissociation between differential stress- induced cortic testosterone responses and regulation of hippocampal GR levels in prepubertal and adult animals.
Journal ArticleDOI

Effects of adrenalectomy and Type I or Type II glucocorticoid receptor activation on AVP and CRH mRNA in the rat hypothalamus

TL;DR: In agreement with previous reports, adrenal steroid regulation of AVP and CRH mRNA was found to be mediated primarily through the Type II receptor.
Book ChapterDOI

Neuroendocrine aspects of adaptation.

TL;DR: Results of glucocorticoid actions during the diurnal cycle modify synaptic efficacy within a hippocampal system that is involved in learning and memory and is also influenced by the neuropeptide, vasopressin.
Journal ArticleDOI

A biphasic regulation of receptor mRNA expressions for growth hormone, glucocorticoid and mineralocorticoid in the rat dentate gyrus during acute stress.

TL;DR: Results have suggested that the GHR mRNA expression in the DG is regulated, at least in part, by glucocorticoids and that GH may be involved in responses of the DG to acute stress.
Journal ArticleDOI

Lithium's role in neural plasticity and its implications for mood disorders.

TL;DR: What is known about the molecular mechanisms underlying Li's actions in the brain in response to stress is summarized, particularly how Li is able to facilitate plasticity through regulation of the glutamate system and cytoskeletal components.