Bruce S. McEwen

TL;DR: It is suggested that acute stress, by activating glucocorticoid receptors, increases the trafficking and function of NMDARs and AMPARs through SGK/Rab4 signaling, which leads to the potentiated synaptic transmission, thereby facilitating cognitive processes mediated by the PFC.

TL;DR: Large differences in the diurnal and stress corticosterone (CORT) profiles of these three genetically related strains are reported, and it is investigated whether the substantial differences between strains in levels of CORT and CBG, in the context of few strain differences in post-adrenalectomy adrenal steroid receptor levels in neural and immune tissue, translate into differences in receptor occupancy/activation under resting conditions, or following stress.

TL;DR: Findings of organ weight changes, enhanced basal CORT, and reduced CORT response to stress in a subgroup of animals are similar to many of the phenomena obtained with other intense, chronic stressors such as subordination, and suggest that repeated predator exposure produces a pattern of intense behavioral and endocrine response that is very slow to habituate.

TL;DR: The results suggest that stress-induced dendritic plasticity in the medial PFC is reversible and may have implications for the functional recovery of medial P FC function following prolonged psychological stress.

TL;DR: Hormonal and neural responses in prepubertal and adult male rats after exposure to acute or more chronic restraint stress indicate that experience-dependent plasticity of the hypothalamic-pituitary-adrenal neuroendocrine axis is significantly influenced by pubertal maturation.