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Bruce S. McEwen
Researcher at Rockefeller University
Publications - 1168
Citations - 214913
Bruce S. McEwen is an academic researcher from Rockefeller University. The author has contributed to research in topics: Hippocampus & Hippocampal formation. The author has an hindex of 215, co-authored 1163 publications receiving 200638 citations. Previous affiliations of Bruce S. McEwen include Yale University & National Institutes of Health.
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Journal ArticleDOI
Allostatic Load as a Complex Clinical Construct: A Case-Based Computational Modeling Approach
J. Galen Buckwalter,Brian Castellani,Bruce S. McEwen,Arun S. Karlamangla,Albert Rizzo,Bruce Sheffield John,Kyle O'donnell,Teresa E. Seeman +7 more
TL;DR: This work developed a multisystem, 7-factor (20 biomarker) model of AL's network of allostatic systems, and used it to create a catalog of nine different clinical AL profiles (causal pathways), which linked each clinical profile to a typology of 23 health outcomes.
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Mother lowers glucocorticoid levels of preweaning rats after acute threat.
TL;DR: It is demonstrated that social variables can reduce the consequences of an aversive experience and exposure to a deadly threat, an adult male rat, induced the release of corticosterone in 14‐day‐old rat pups.
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Hippocampal mossy fiber leu-enkephalin immunoreactivity in female rats is significantly altered following both acute and chronic stress.
Joseph P. Pierce,David T. Kelter,Bruce S. McEwen,Elizabeth M. Waters,Teresa A. Milner,Teresa A. Milner +5 more
TL;DR: Findings suggest that alterations in leu-enkephalin levels following stress could play an important role in the sex-specific responses that females display in learning processes, including those important in addiction.
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Characteristics of Estradiol-Binding Macromolecules in Fetal and Adult Guinea Pig Brain Cytosols
TL;DR: Results offl Vitro binding experiments with H-estradiol indicate that cytosol prepared from the adult brain contains at least two popula- tions of estradiol-binding macromolecules, and it seems unlikely that a fetal-specific estradio-binding protein, comparable to rat alphafetoprotein, is present in fetal guinea pig brain or plasma.
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Light-dark differences in behavioral sensitivity to oxytocin.
TL;DR: Female rats treated with physiological amounts of ovarian hormones and OT are more sensitive to the facilitative effects of the OT on lordosis behavior during the dark phase of the light-dark cycle.