B
Bruce S. McEwen
Researcher at Rockefeller University
Publications - 1168
Citations - 214913
Bruce S. McEwen is an academic researcher from Rockefeller University. The author has contributed to research in topics: Hippocampus & Hippocampal formation. The author has an hindex of 215, co-authored 1163 publications receiving 200638 citations. Previous affiliations of Bruce S. McEwen include Yale University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Uncovering the mechanisms of estrogen effects on hippocampal function.
Joanna L. Spencer,Elizabeth M. Waters,Russell D. Romeo,Russell D. Romeo,Gwendolyn E. Wood,Teresa A. Milner,Teresa A. Milner,Bruce S. McEwen +7 more
TL;DR: The effects of estrogen in the hippocampal formation that lead to modulation of hippocampal function include effects on cell morphology, synapse formation, signaling, and excitability that have been studied in laboratory mice, rats, and primates.
Journal ArticleDOI
Differential Regulation of NMDAR1 mRNA and Protein by Estradiol in the Rat Hippocampus
TL;DR: The data suggest that estradiol modulates NMDA receptor function via post-transcriptional regulation of the NMDAR1 subunit protein, which could account for estrogen-induced changes in pharmacological and physiological properties of the NMDA receptors.
Journal ArticleDOI
Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders.
TL;DR: From a therapeutic standpoint, it is essential to distinguish between permanent damage and reversible atrophy in order to develop treatment strategies to either prevent or reverse deficits, and remodeling of brain cells may occur in other brain regions.
Journal ArticleDOI
Observations in a preliminary open trial of estradiol therapy for senile dementia-Alzheimer's type.
Howard Fillit,Herman Weinreb,Ina N. Cholst,Victoria N. Luine,Bruce S. McEwen,Roberto Amador,John B. Zabriskie +6 more
TL;DR: The occurrence of osteoporosis in the estrogen-responsive group suggests that SDAT in some women may be associated with or related to a systemic estrogen deficiency state, but the current risk to benefit ratio precludes the routine clinical use of estrogen for dementia until careful clinical research trials have been performed.
Journal ArticleDOI
Uncertainty and stress: Why it causes diseases and how it is mastered by the brain.
TL;DR: Based on the basic tenet that stress originates from uncertainty, an information‐theoretic approach – based on the ‘free energy principle’ – defining the essence of stress; namely, uncertainty is presented.