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Bruce S. McEwen
Researcher at Rockefeller University
Publications - 1168
Citations - 214913
Bruce S. McEwen is an academic researcher from Rockefeller University. The author has contributed to research in topics: Hippocampus & Hippocampal formation. The author has an hindex of 215, co-authored 1163 publications receiving 200638 citations. Previous affiliations of Bruce S. McEwen include Yale University & National Institutes of Health.
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Corticosterone Regulation of Tryptophan Hydroxylase in Midbrain of the Rat
TL;DR: The tryptophan hydroxylase activity in the rat midbrain decreases after adrenalectomy and is restored by treatment with cortic testosterone, an indication that the enzyme has a rapid turnover even in the absence of corticosterone.
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Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat.
TL;DR: Results indicate that type I adrenal steroid receptor activation is sufficient to protect against adrenalectomy-induced cell death.
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Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment
TL;DR: It is demonstrated that chronic treatment with lithium can protect the hippocampus from potentially deleterious effects of chronic stress on glutamatergic activation, which may be relevant to its therapeutic efficacy in the treatment of major depressive disorder and bipolar disorder.
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Differential stress reactivity in intact and ovariectomized prepubertal and adult female rats.
TL;DR: Investigation of stress responsiveness, as measured by both stress hormones and gonadal steroids, in intact and ovariectomized prepubertal and adult female rats before and after a 30-min session of restraint stress indicates that stress reactivity changes dramatically during puberty in females.
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Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle.
Xenia Protopopescu,Hong Pan,Margaret Altemus,Oliver Tuescher,Margaret Polanecsky,Bruce S. McEwen,David Silbersweig,Emily Stern +7 more
TL;DR: Findings suggest that specific subregional OFC activity to emotional stimuli is modulated across the menstrual cycle, and demonstrate that menstrual cycle phase is an important consideration in further studies attempting to elucidate the neural substrates of affective representation.