Bruce S. McEwen

TL;DR: Hormones secreted by the adrenals, gonads and thyroid play an important role in mediating how the environment shapes the structure and function of the brain during early development, adult life and senescence.

TL;DR: It is concluded that the HPA neuroendocrine axis is further shaped during pubertal development to allow for the emergence of a more tightly regulated stress response in adulthood.

TL;DR: The role of mitochondrial energetics and redox balance as modulators of key pathophysiological perturbations previously linked to disease is demonstrated, establishing mitochondria as stress-response modulators, with implications for understanding the mechanisms of stress pathophysiology and mitochondrial diseases.

TL;DR: Because there is no significant nuclear accumulation of [3H]-alpha-testosterone in either the entorhinal cortex or hippocampal formation, it appears that aromatase enzyme activity is not a major contributor to estrogen receptor occupancy in adult rats.

TL;DR: An essential role for Akt is demonstrated in estrogen-stimulated dendritic spine protein expression, for the first time a signal transduction pathway in PSD-95 expression is described, and a novel, molecular mechanism by which ovarian hormones might translationally regulate synaptogenesis via activating protein synthesis for dendrite function is delineated.