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Bruce S. McEwen

Researcher at Rockefeller University

Publications -  1168
Citations -  214913

Bruce S. McEwen is an academic researcher from Rockefeller University. The author has contributed to research in topics: Hippocampus & Hippocampal formation. The author has an hindex of 215, co-authored 1163 publications receiving 200638 citations. Previous affiliations of Bruce S. McEwen include Yale University & National Institutes of Health.

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Dihydrotestosterone increases hippocampal N-methyl-D-aspartate binding but does not affect choline acetyltransferase cell number in the forebrain or choline transporter levels in the CA1 region of adult male rats.

TL;DR: It is found that DHT significantly increased NMDA receptor binding in the CA1 region of males but had no effect on ChAT cell number in the forebrain or hemicholinium-3-sensitive choline transporter protein levels in theCA1 region, which indicates that, similar to E-induced spinogenesis in females, DHT-induced increases in spine formation in males may require increases in NMDA receptors.
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Steroid regulation and sex differences in [(3) h]muscimol binding in hippocampus, hypothalamus and midbrain in rats.

TL;DR: There is a sex difference in the level of binding in the very caudal ventromedial nucleus of the hypothalamus in males and females, and these effects may be functionally related to GABAergic control of female sexual behavior.
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Accumulation of resident and peripheral dendritic cells in the aging CNS

TL;DR: The numerical and phenotypic changes in bDC indicate these cells may serve as an important immune component in the functional and anatomic alterations associated with aging.
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High-affinity binding of corticosterone to mammalian neuronal membranes: possible role of corticosteroid binding globulin.

TL;DR: Data suggest that corticosteroid binding globulins may facilitate [3H]corticosterone binding to neuronal membranes, however, the addition of blood to perfused brains before homogenization did not restore high-affinity binding, so the role of plasma binding Globulins is unclear.
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Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation

TL;DR: It is speculated that gp130 cytokines play a paracrine, neuromodulatory role in the hippocampus since both before and after seizure, principal cells appear to be the major cell type expressing the receptors for these cytokines.