Bruce S. McEwen

TL;DR: This chapter discusses the broad outlines of two major modes of hormone action on target cells, and a discussion of this topic forms the central theme around which this chapter revolves.

TL;DR: The results show a marked change in CGRP‐IR in regions of the hippocampus that are temporally and anatomically correlated with the induction of apoptosis and activation of microglia, astrocyte, and the cell‐cycle marker, consistent with a regional immunoregulatory/injury response role for C GRP following organotin poisoning.

TL;DR: The results demonstrate that adrenal effects on adenylate case activity are regionally specific within the brain, and suggest that other adrenal secretions besides glucocorticoids may be involved in the feedback of the diurnal rhythm on the hippocampus.

TL;DR: It is demonstrated that CIS females, but not males, acquire conditioned place preference (CPP) to Oxycodone and that CIS “primes” the hippocampal opioid system in females for oxycodone‐associated learning and that low levels of DORs in MF‐CA3 synapses and hilar GABAergic interneurons may contribute to the attenuation of oxycod one CPP in males exposed to CIS.

TL;DR: The findings suggest that FGF2 may exert its anxiolytic effects in male MS rats by a compensatory increase in the acetylation of the OTR promoter to overcome reduced OT levels in the BNST.