Bruce S. McEwen

TL;DR: Tyrosine hydroxylase mRNA levels measured with in situ hybridization were elevated in locus coeruleus of NRS compared to singly or pair-housed controls; NRS also had higher TH levels than dominants.

TL;DR: The data presented here indicate that CRS alters the transcriptional response to a subsequent GC injection, and it is proposed that this altered transcriptional potential forms part of the molecular mechanism underlying the enhanced vulnerability for stress-related disorders like depression caused by chronic stress.

TL;DR: The results show that sustained exposure to GCs produces obesity and metabolic syndrome through a peripheral endocannabinoid mechanism, and indicate that glucocorticoids recruit peripheral endOCannabinoid signaling to promote metabolic dysregulation, with hepatic endoc cannabinoid signaling being especially important for changes in lipid metabolism.

TL;DR: Levels of 5HT in the female brain were significantly higher than those in the male on postnatal days 10, 12, and 14, though not on days 2, 4, and 8 or on days 16 and 25.

TL;DR: Results indicate that acute elevated platform stress down-regulates a putative BDNF/MEK/MAPK signaling cascade in the frontal cortex in a manner that is reversible by the antidepressants tianeptine and imipramine.