B
Bruce S. McEwen
Researcher at Rockefeller University
Publications - 1168
Citations - 214913
Bruce S. McEwen is an academic researcher from Rockefeller University. The author has contributed to research in topics: Hippocampus & Hippocampal formation. The author has an hindex of 215, co-authored 1163 publications receiving 200638 citations. Previous affiliations of Bruce S. McEwen include Yale University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Estrogen and the aging brain: an elixir for the weary cortical network
TL;DR: Future studies are focused on identifying the most clinically relevant hormone treatment, as well as the potential identification of new therapeutics that can prevent or reverse age‐related cognitive impairment by intercepting specific signal transduction pathways initiated by estrogen.
Journal ArticleDOI
Estrogen and ovariectomy regulate mRNA and protein of glutamic acid decarboxylases and cation-chloride cotransporters in the adult rat hippocampus.
TL;DR: The findings suggest that basal levels of estrogen might contribute to a balance between the excitatory and inhibitory synaptic transmission onto CA1 pyramidal cells by regulating perisomatic GAD and NKCC1 expression in the adult hippocampus.
Journal ArticleDOI
PSA-NCAM expression in the piriform cortex of the adult rat. Modulation by NMDA receptor antagonist administration.
TL;DR: The results expand the current knowledge of the neuronal populations expressing PSA-NCAM in the piriform cortex, suggesting that some of these cells could be involved in structural plastic events such as axonal outgrowth, synaptogenesis or even neuronal migration.
Journal ArticleDOI
Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History
J. Annelies E. Polman,Richard G. Hunter,Niels Speksnijder,Jessica M.E. van den Oever,Oksana B. Korobko,Bruce S. McEwen,E. Ronald de Kloet,Nicole A. Datson +7 more
TL;DR: It is proposed that direct regulation of the mTOR pathway by GC represents an important mechanism regulating neuronal plasticity in the rat DG, which changes after exposure to chronic stress.
Journal ArticleDOI
N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus
Juan Nacher,Emilio Varea,J. Miguel Blasco-Ibáñez,María Ángeles Gómez-Climent,Esther Castillo-Gómez,Carlos Crespo,F.J. Martínez-Guijarro,Bruce S. McEwen +7 more
TL;DR: The results demonstrate that adult hippocampal neurogenesis may be regulated by NMDA receptors present in precursor cells and in differentiating granule neurons, although these receptors are probably not located on synapses, although an indirect effect through NMDA receptor located in other cell types should not be excluded.