Bruce S. McEwen

TL;DR: The present studies indicate that estrogen can modulate LENK in subregions of the MF pathway in a dose-and time-dependent manner and might be triggered by direct activation of ERbeta or PR in LENk-containing terminals.

TL;DR: Evidence is provided that the conversion of testosterone to estradiol may play a decisive role in the sexual differentiation of the rat brain and the effectiveness of estrogens and aromatizable androgens on this process and the ineffectiveness of A-ring reduced androgens; and indications that anti-estrogens such as MER-25 may attenuate the actions of testosterone.

TL;DR: The concentration of estrogen-induced cytosolic progestin receptors in the hypothalamus of alpha 1-noradrenergic antagonist-treated female guinea pigs is reduced relative to non-drug-treated controls, and where within the hypothalamic area nuclei this reduction occurs is determined.

TL;DR: In aged rats there are changes in the adaptive mechanisms contributing to tolerance of the HPA axis response to ethanol, which is suggested to be secondary to a generalized dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis.

TL;DR: It is suggested that hippocampal levels of phosphorylated DORs vary with estrous cycle phase and that acute stress may dampen the differential effects of hormones on DOR activation in females.