Bruce S. McEwen

TL;DR: The concept of allostasis is discussed, maintaining stability through change, as a fundamental process through which organisms actively adjust to both predictable and unpredictable events, using the balance between energy input and expenditure as the basis for applying the concept.

TL;DR: The goal in the study of aging is not to halt the aging process, because we can no more be cured of aging than of birth as mentioned in this paper, but to slow and soften the sharpest edges of the biological unraveling that constitutes aging.

TL;DR: The goal in the study of aging is not to halt the process, because the authors can no more be cured of aging than of birth, but to slow and soften the sharpest edges of the biological unraveling that constitutes aging.

TL;DR: A scientific consensus is emerging that the origins of adult disease are often found among developmental and biological disruptions occurring during the early years of life as mentioned in this paper, and that these early experiences can affect adult health in 2 ways: cumulative damage over time or by the biological embedding of adversities during sensitive developmental periods.

TL;DR: The hippocampus is a target of stress hormones, and it is an especially plastic and vulnerable region of the brain that undergoes a selective atrophy in a number of disorders, accompanied by deficits in declarative episodic, spatial, and contextual memory performance.