C
Claire M. Healy
Researcher at Trinity College, Dublin
Publications - 107
Citations - 11952
Claire M. Healy is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Cancer & Odds ratio. The author has an hindex of 37, co-authored 103 publications receiving 10973 citations. Previous affiliations of Claire M. Healy include Royal College of Surgeons in Ireland & University College Dublin.
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Journal ArticleDOI
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Richa Saxena,Benjamin F. Voight,Valeriya Lyssenko,Noël P. Burtt,Paul I.W. de Bakker,Hong Chen,Jeffrey J. Roix,Sekar Kathiresan,Joel N. Hirschhorn,Mark J. Daly,Thomas E. Hughes,Leif Groop,David Altshuler,Peter Almgren,Jose C. Florez,Joanne M. Meyer,Kristin Ardlie,Kristina Bengtsson Boström,Bo Isomaa,Guillaume Lettre,Ulf Lindblad,Helen N. Lyon,Olle Melander,Christopher Newton-Cheh,Peter Nilsson,Marju Orho-Melander,Lennart Råstam,Elizabeth K. Speliotes,Marja-Riitta Taskinen,Tiinamaija Tuomi,Candace Guiducci,Anna Berglund,Joyce Carlson,Lauren Gianniny,Rachel Hackett,Liselotte Hall,Johan Holmkvist,Esa Laurila,Marketa Sjögren,Maria Sterner,Aarti Surti,Margareta Svensson,Malin Svensson,Ryan Tewhey,Brendan Blumenstiel,Melissa Parkin,Matthew DeFelice,Rachel Barry,Wendy Brodeur,Jody Camarata,Nancy Chia,Mary Fava,John G. Gibbons,Bob Handsaker,Claire M. Healy,Kieu Nguyen,Casey Gates,Carrie Sougnez,Diane Gage,Marcia M. Nizzari,Stacey Gabriel,Gung-Wei Chirn,Qicheng Ma,Hemang Parikh,Delwood Richardson,Darrell O. Ricke,Shaun Purcell +66 more
TL;DR: The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Journal ArticleDOI
Genome sequence, comparative analysis and haplotype structure of the domestic dog
Kerstin Lindblad-Toh,Claire M. Wade,Claire M. Wade,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Elinor K. Karlsson,Elinor K. Karlsson,David B. Jaffe,Michael Kamal,Michele Clamp,Jean L. Chang,Edward J. Kulbokas,Michael C. Zody,Evan Mauceli,Xiaohui Xie,Matthew Breen,Robert K. Wayne,Elaine A. Ostrander,Chris P. Ponting,Francis Galibert,Douglas Smith,Pieter J. deJong,Ewen F. Kirkness,Pablo Alvarez,Tara Biagi,William Brockman,Jonathan Butler,Chee-Wye Chin,April Cook,James Cuff,Mark J. Daly,Mark J. Daly,David DeCaprio,Sante Gnerre,Manfred Grabherr,Manolis Kellis,Michael Kleber,Carolyne Bardeleben,Leo Goodstadt,Andreas Heger,Christophe Hitte,Lisa Kim,Klaus-Peter Koepfli,Heidi G. Parker,John P. Pollinger,Stephen M. J. Searle,Nathan B. Sutter,Rachael Thomas,Caleb Webber,Jennifer Baldwin,Jennifer Baldwin,Adal Abebe,Amr Abouelleil,Lynne Aftuck,Mostafa Ait-zahra,Tyler Aldredge,Nicole R. Allen,Peter An,Scott Anderson,Claudel Antoine,Harindra Arachchi,Ali Aslam,Laura Ayotte,Pasang Bachantsang,Andrew Barry,Tashi Bayul,Mostafa Benamara,Aaron M. Berlin,Daniel Bessette,Berta Blitshteyn,Toby Bloom,Jason Blye,Leonid Boguslavskiy,Claude Bonnet,Boris Boukhgalter,Adam Brown,Patrick Cahill,Nadia Calixte,Jody Camarata,Yama Cheshatsang,Jeffrey Chu,Mieke Citroen,Alville Collymore,Patrick Cooke,Tenzin Dawoe,Riza M. Daza,Karin Decktor,Stuart DeGray,Norbu Dhargay,Kimberly Dooley,Kathleen Dooley,Passang Dorje,Kunsang Dorjee,Lester Dorris,Noah Duffey,Alan Dupes,Osebhajajeme Egbiremolen,Richard Elong,Jill Falk,Abderrahim Farina,Susan Faro,Diallo Ferguson,Patricia Ferreira,Sheila A. Fisher,Michael Fitzgerald,Karen Foley,Chelsea D. Foley,Alicia Franke,Dennis C. Friedrich,Diane Gage,Manuel Garber,Gary Gearin,Georgia Giannoukos,Tina Goode,Audra Goyette,Joseph Graham,Edward Grandbois,Kunsang Gyaltsen,Nabil Hafez,Daniel S. Hagopian,Birhane Hagos,Jennifer Ruth Sadler Hall,Claire M. Healy,Ryan Hegarty,Tracey Honan,Andrea Horn,Nathan Houde,Leanne Hughes,Leigh Anne Hunnicutt,M. Husby,Benjamin Jester,Charlien Jones,Asha Kamat,Ben Kanga,Cristyn Kells,Dmitry Khazanovich,Alix Chinh Kieu,Peter Kisner,Mayank Kumar,Krista Lance,Thomas E. Landers,Marcia Lara,William H. Lee,Jean-Pierre Leger,Niall J. Lennon,Lisa Leuper,Sarah LeVine,Jinlei Liu,Xiaohong Liu,Yeshi Lokyitsang,Tashi Lokyitsang,Annie Lui,Jan Macdonald,John E. Major,Richard Marabella,Kebede Maru,Charles Matthews,Susan McDonough,Teena Mehta,James Meldrim,Alexandre Melnikov,Louis Meneus,Atanas Mihalev,Tanya Mihova,Karen Hughes Miller,Rachel Mittelman,Valentine Mlenga,Leonidas Mulrain,Glen Munson,Adam Navidi,Jerome Naylor,Tuyen T. Nguyen,Nga Nguyen,Cindy Nguyen,Thu Nguyen,Robert Nicol,Nyima Norbu,Choe Norbu,Nathaniel Novod,Tenchoe Nyima,Peter Olandt,Barry O'Neill,Keith O'Neill,Sahal Osman,Lucien Oyono,Christopher Patti,Danielle Perrin,Pema Phunkhang,Fritz Pierre,Margaret Priest,Anthony Rachupka,Sujaa Raghuraman,Rayale Rameau,Verneda Ray,Christina Raymond,Filip Rege,Cecil Rise,Julie Rogers,Peter Rogov,Julie Sahalie,Sampath Settipalli,Ted Sharpe,Terrance Shea,Mechele Sheehan,Ngawang Sherpa,Jianying Shi,Diana M. Shih,Jessie Sloan,Cherylyn Smith,Todd Sparrow,John Stalker,Nicole Stange-Thomann,Sharon Stavropoulos,Catherine Stone,Sabrina M. Stone,Sean M. Sykes,Pierre Tchuinga,Pema Tenzing,Senait Tesfaye,Dawa Thoulutsang,Yama Thoulutsang,Kerri Topham,Ira Topping,Tsamla Tsamla,Helen Vassiliev,Vijay Venkataraman,Andy Vo,Tsering Wangchuk,Tsering Wangdi,Michael Weiand,Jane E. Wilkinson,Adam Wilson,Shailendra Yadav,Shuli Yang,Xiaoping Yang,Geneva Young,Qing Yu,Joanne Zainoun,Lisa Zembek,Andrew Zimmer,Eric S. Lander,Eric S. Lander +241 more
TL;DR: A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes.
Journal ArticleDOI
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
Rayjean J. Hung,James McKay,Valerie Gaborieau,Paolo Boffetta,Mia Hashibe,David Zaridze,Anush Mukeria,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Chu Chen,Gary E. Goodman,John K. Field,Triantafillos Liloglou,George Xinarianos,Adrian Cassidy,John R. McLaughlin,Geoffrey Liu,Steven A. Narod,Hans E. Krokan,Frank Skorpen,Maiken Bratt Elvestad,Kristian Hveem,Lars J. Vatten,Jakob Linseisen,Françoise Clavel-Chapelon,Paolo Vineis,H. Bas Bueno-de-Mesquita,Eiliv Lund,Carmen Martinez,Sheila Bingham,Torgny Rasmuson,Pierre Hainaut,Elio Riboli,Wolfgang Ahrens,Simone Benhamou,Pagona Lagiou,Dimitrios Trichopoulos,Ivana Holcatova,Franco Merletti,Kristina Kjærheim,Antonio Agudo,Gary J. Macfarlane,Renato Talamini,Lorenzo Simonato,Ray Lowry,David I. Conway,Ariana Znaor,Claire M. Healy,Diana Zelenika,Anne Boland,Marc Delepine,Mario Foglio,Doris Lechner,Fumihiko Matsuda,Hélène Blanché,Ivo Gut,Simon Heath,Mark Lathrop,Paul Brennan +64 more
TL;DR: The results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets.
Journal ArticleDOI
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Helena Furberg,Yunjung Kim,Jennifer Dackor,Eric Boerwinkle,Nora Franceschini,Diego Ardissino,Luisa Bernardinelli,Luisa Bernardinelli,Pier Mannuccio Mannucci,Francesco Mauri,Piera Angelica Merlini,Devin Absher,Themistocles L. Assimes,Stephen P. Fortmann,Carlos Iribarren,Joshua W. Knowles,Thomas Quertermous,Luigi Ferrucci,Toshiko Tanaka,Joshua C. Bis,Curt D. Furberg,Talin Haritunians,Barbara McKnight,Bruce M. Psaty,Bruce M. Psaty,Kent D. Taylor,Evan L. Thacker,Peter Almgren,Leif Groop,Claes Ladenvall,Michael Boehnke,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Jaakko Tuomilehto,Jaakko Tuomilehto,Emelia J. Benjamin,Shih-Jen Hwang,Daniel Levy,Sarah R. Preis,Ramachandran S. Vasan,Jubao Duan,Pablo V. Gejman,Douglas F. Levinson,Alan R. Sanders,Jianxin Shi,Esther H. Lips,James McKay,Antonio Agudo,Luigi Barzan,Vladimir Bencko,Simone Benhamou,Simone Benhamou,Xavier Castellsagué,Cristina Canova,David I. Conway,Eleonora Fabianova,Lenka Foretova,Vladimir Janout,Claire M. Healy,Ivana Holcatova,Kristina Kjærheim,Pagona Lagiou,Jolanta Lissowska,Ray Lowry,Tatiana V. Macfarlane,Dana Mates,Lorenzo Richiardi,Peter Rudnai,Neonilia Szeszenia-Dabrowska,David Zaridze,Ariana Znaor,Mark Lathrop,Paul Brennan,Stefania Bandinelli,Timothy M. Frayling,Jack M. Guralnik,Yuri Milaneschi,John R. B. Perry,David Altshuler,David Altshuler,Roberto Elosua,S. Kathiresan,S. Kathiresan,Gavin Lucas,Olle Melander,Christopher J. O'Donnell,Veikko Salomaa,Stephen M. Schwartz,Benjamin F. Voight,Brenda W.J.H. Penninx,Johannes H. Smit,Nicole Vogelzangs,Dorret I. Boomsma,Eco J. C. de Geus,Jacqueline M. Vink,Gonneke Willemsen,Stephen J. Chanock,Fangyi Gu,Susan E. Hankinson,David J. Hunter,Albert Hofman,Henning Tiemeier,André G. Uitterlinden,Cornelia M. van Duijn,Stefan Walter,Daniel I. Chasman,Brendan M. Everett,Guillaume Paré,Paul M. Ridker,Ming D. Li,Hermine H. Maes,Janet Audrain-McGovern,Danielle Posthuma,Laura M. Thornton,Caryn Lerman,Jaakko Kaprio,Jaakko Kaprio,Jed E. Rose,John P. A. Ioannidis,John P. A. Ioannidis,Peter Kraft,Danyu Lin,Patrick F. Sullivan +123 more
TL;DR: A meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium found the strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3, and three loci associated with number of cigarettes smoked per day were identified.
Journal ArticleDOI
A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
James McKay,Thérèse Truong,Valerie Gaborieau,Amelie Chabrier,Shu Chun Chuang,Graham Byrnes,David Zaridze,Oxana Shangina,Neonila Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Alexandru Bucur,Vladimir Bencko,Ivana Holcatova,Vladimir Janout,Lenka Foretova,Pagona Lagiou,Dimitrios Trichopoulos,Simone Benhamou,Christine Bouchardy,Wolfgang Ahrens,Franco Merletti,Lorenzo Richiardi,Renato Talamini,Luigi Barzan,Kristina Kjærheim,Gary J. Macfarlane,Tatiana V. Macfarlane,Lorenzo Simonato,Cristina Canova,Cristina Canova,Antonio Agudo,Xavier Castellsagué,Ray Lowry,David I. Conway,Patricia A. McKinney,Claire M. Healy,Mary Toner,Ariana Znaor,Maria Paula Curado,Sergio Koifman,Ana M. B. Menezes,Victor Wünsch-Filho,José Eluf Neto,Leticia Fernández Garrote,Stefania Boccia,Gabriella Cadoni,Dario Arzani,Andrew F. Olshan,Mark C. Weissler,William K. Funkhouser,Jingchun Luo,Jan Lubinski,Joanna Trubicka,Marcin Lener,Dorota Oszutowska,Stephen M. Schwartz,Chu Chen,Sherianne Fish,David R. Doody,Joshua E. Muscat,Philip Lazarus,Carla J. Gallagher,Shen Chih Chang,Zuo-Feng Zhang,Qingyi Wei,Erich M. Sturgis,Li E. Wang,Silvia Franceschi,Rolando Herrero,Karl T. Kelsey,Michael D. McClean,Carmen J. Marsit,Heather H. Nelson,Marjorie Romkes,Shama Buch,Tomoko Nukui,Shilong Zhong,Martin Lacko,Johannes J. Manni,Wilbert H.M. Peters,Rayjean J. Hung,John R. McLaughlin,Lars J. Vatten,Inger Njølstad,Gary E. Goodman,John K. Field,Triantafillos Liloglou,Paolo Vineis,Paolo Vineis,Françoise Clavel-Chapelon,Domenico Palli,Rosario Tumino,Vittorio Krogh,Salvatore Panico,Carlos A. González,J. Ramón Quirós,Carmen Enid Martínez,Carmen Navarro,Eva Ardanaz,Nerea Larrañaga,Kay-Tee Khaw,Timothy J. Key,H. Bas Bueno-de-Mesquita,Petra H.M. Peeters,Antonia Trichopoulou,Jakob Linseisen,Heiner Boeing,Göran Hallmans,Kim Overvad,Anne Tjønneland,Merethe Kumle,Elio Riboli,Kristjan Välk,Tõnu Voodern,Andres Metspalu,Diana Zelenika,Anne Boland,Marc Delepine,Mario Foglio,Doris Lechner,Hélène Blanché,Ivo Gut,Pilar Galan,Simon Heath,Mia Hashibe,Richard B. Hayes,Paolo Boffetta,Mark Lathrop,Paul Brennan +130 more
TL;DR: A genome-wide association study to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.