Marmar Moussa

TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.

TL;DR: The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally conserved across mammals, and a broadly conserved cellular makeup is demonstrated, whose similarity mirrors evolutionary distance and is consistent between the transcriptome and epigenome.

TL;DR: Novel computational approaches for clustering scRNA-seq data based on the Term Frequency - Inverse Document Frequency (TF-IDF) transformation that has been successfully used in the field of text analysis are presented.

TL;DR: This article studies some existing single cell RNA sequencing imputation methods and proposes a novel iterative imputation approach based on efficiently computing highly similar cells and presents the results of a comprehensive assessment of existing and proposed methods on real scRNA-Seq data sets with varying per cell sequencing depth.

TL;DR: T cells elicited by the active neoepitopes identified here demonstrated a stem-like early dysfunctional phenotype associated with effective responses against viruses and tumors of transgenic mice, which can be exploited for generation of personalized human cancer vaccines.