Nikolas L. Jorstad

TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.

TL;DR: The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally conserved across mammals, and a broadly conserved cellular makeup is demonstrated, whose similarity mirrors evolutionary distance and is consistent between the transcriptome and epigenome.

TL;DR: In this article, the authors leveraged the recent discovery of a transcriptomically defined L5 extratelencephalic-projecting (ET) neuron type to study the properties of human L5 ET neurons in neocortical brain slices derived from neurosurgeries.

TL;DR: Patch-seq recordings revealed many conserved morpho-electric properties of human and rodent L5 ET neurons, which suggest a conserved function of L5ET neurons in the neocortical hierarchy, but also highlight marked phenotypic divergence possibly related to functional specialization of human neocortex.

TL;DR: In this article, the authors report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (BICCN).