Nora Reed

TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.

TL;DR: This study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps, and establishes a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.

TL;DR: An interneuron type that was previously associated with the mouse hippocampus—the ‘ivy cell’, which has neurogliaform characteristics— has become abundant across the neocortex of humans, macaques and marmosets but not mice or ferrets, and a notable subcortical innovation is found.

TL;DR: The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally conserved across mammals, and a broadly conserved cellular makeup is demonstrated, whose similarity mirrors evolutionary distance and is consistent between the transcriptome and epigenome.

TL;DR: Drop-seq used to profile RNA expression in telencephalic interneurons from humans, macaques, marmosets, and mice identified an abundant striatal interneuron type in primates that had no molecularly homologous cell population in mouse striatum, cortex, thalamus, or hippocampus.