T
Trevor W. Robbins
Researcher at University of Cambridge
Publications - 1184
Citations - 177352
Trevor W. Robbins is an academic researcher from University of Cambridge. The author has contributed to research in topics: Prefrontal cortex & Cognition. The author has an hindex of 231, co-authored 1137 publications receiving 164437 citations. Previous affiliations of Trevor W. Robbins include Centre national de la recherche scientifique & Massachusetts Institute of Technology.
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Chemical Neuromodulation of Goal-Directed Behavior
TL;DR: Empirical data and theories are reviewed which show that this trade-off depends on optimal modulation of frontostriatal circuitry by the major ascending neuromodulatory systems of dopamine, noradrenaline, and acetylcholine.
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Systemic idazoxan impairs performance in a non-reversal shift test: implications for the role of the central noradrenergic systems in selective attention:
TL;DR: Rats treated with idazoxan were not impaired in the acquisition of either the spatial or visual discrimination task, but they were impaired in both forms of non-reversal shift, thus supporting a selective attention hypothesis of locus coeruleus function.
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Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality
Jonathan W. Kanen,Frederique E. Arntz,Frederique E. Arntz,Robyn Yellowlees,Robyn Yellowlees,Rudolf N. Cardinal,Annabel Price,David M Christmas,Annemieke M. Apergis-Schoute,Annemieke M. Apergis-Schoute,Barbara J. Sahakian,Trevor W. Robbins +11 more
TL;DR: The findings show how individual differences in personality, when combined with fluctuations of serotonin, may produce diverse emotional phenotypes, which has implications for understanding vulnerability to psychopathology, determining who may be more sensitive to serotonin-modulating treatments, and casts new light on the functions of serotonin in emotional processing.
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Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.
Natalia del Campo,Roger Tait,Julio Acosta-Cabronero,Young T. Hong,David Izquierdo-Garcia,Rob Smith,Franklin I. Aigbirhio,Barbara J. Sahakian,Ulrich Müller,Trevor W. Robbins,Tim D. Fryer +10 more
TL;DR: ART spatial normalization combined with probabilistic ROIs and to a lesser extent template ROIs provides an efficient and accurate alternative to time-consuming manual sub-striatal ROI delineation per subject, especially when the parameter of interest is BP(ND) % change.
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Serotonergic Innervations of the Orbitofrontal and Medial-prefrontal Cortices are Differentially Involved in Visual Discrimination and Reversal Learning in Rats.
Johan Alsiö,Olivia Lehmann,Colin McKenzie,David E. H. Theobald,Lydia Searle,Jing Xia,Jeffrey W. Dalley,Trevor W. Robbins +7 more
TL;DR: The understanding of serotonin in cognitive flexibility is extended by revealing differential effects within two subregions of the prefrontal cortex in visual discrimination and reversal learning.