Victoria L. Halperin Kuhns

TL;DR: A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci that improve the prediction of gout in an independent cohort of 334,880 individuals, and implicates the kidney and liver as key target organs and prioritize potential causal genes.

TL;DR: A human interventional study and a new orthologous mouse model are used to suggest a tissue specific pathobiology of the Q141K variant, support an important role for ABCG2 in urate excretion in both the human kidney and intestinal tract, and provide insight into the importance of intestinal urates excretion for serum urate homeostasis.

TL;DR: This review summarizes the current understanding of urate as a disease risk factor and how being of the female sex appears protective and advocates the use of sex differences in urate handling as a potent tool in gaining a further understanding of physiological regulation ofUrate homeostasis and for presenting new avenues for treating the constellation of Urate related pathologies.

TL;DR: A new 3D tubuloid system is developed to isolate the rapid changes in protein localization and gene expression that correlate with altered cell and tubule morphology during cyst initiation and demonstrates methods for interrogating the initiation of ADPKD cystogenesis.

TL;DR: In this article, the identified urate transporters and their organization and function in the renal tubule, the intestinal enterocytes, and other important cell types to provide a fuller understanding of the complicated process of urate homeostasis and its role in human diseases.