Eindhoven University of Technology

About: Eindhoven University of Technology is a education organization based out in Eindhoven, Noord-Brabant, Netherlands. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 22309 authors who have published 52936 publications receiving 1584164 citations. The organization is also known as: Technische Hogeschool Eindhoven & TU/e.

Smart cancer nanomedicine

Abstract: Nanomedicines are extensively employed in cancer therapy. We here propose four strategic directions to improve nanomedicine translation and exploitation. (1) Patient stratification has become common practice in oncology drug development. Accordingly, probes and protocols for patient stratification are urgently needed in cancer nanomedicine, to identify individuals suitable for inclusion in clinical trials. (2) Rational drug selection is crucial for clinical and commercial success. Opportunistic choices based on drug availability should be replaced by investments in modular (pro)drug and nanocarrier design. (3) Combination therapies are the mainstay of clinical cancer care. Nanomedicines synergize with pharmacological and physical co-treatments, and should be increasingly integrated in multimodal combination therapy regimens. (4) Immunotherapy is revolutionizing the treatment of cancer. Nanomedicines can modulate the behaviour of myeloid and lymphoid cells, thereby empowering anticancer immunity and immunotherapy efficacy. Alone and especially together, these four directions will fuel and foster the development of successful cancer nanomedicine therapies.

Amplification of chirality in dynamic supramolecular aggregates

Abstract: The quest to understand the origin of chirality in biological systems has evoked an intense search for nonlinear effects in catalysis and pathways to amplify slight enantiomeric excesses in racemates to give optically pure molecules. The amplification of chirality in polymeric systems as a result of cooperative processes has been intensely investigated. Ten years ago, this effect was shown for the first time in noncovalent dynamic supramolecular systems. Since then, it has become clear that a subtle interplay of noncovalent interactions such as hydrogen-bonding, pi-pi stacking, and hydrophobic interactions is also sufficient to observe amplification of chirality in small molecules. Here we summarize the results obtained over the past decade and the general guidelines we can deduce from them. Predicting amplification of chirality is still impossible, but it appears to be a balance between different types of interactions, the formation of an intrinsically chiral object, and cooperative aggregation processes.

COVID-19 and the workplace: Implications, issues, and insights for future research and action.

Abstract: The impacts of COVID-19 on workers and workplaces across the globe have been dramatic. This broad review of prior research rooted in work and organizational psychology, and related fields, is intended to make sense of the implications for employees, teams, and work organizations. This review and preview of relevant literatures focuses on (a) emergent changes in work practices (e.g., working from home, virtual teamwork) and (b) emergent changes for workers (e.g., social distancing, stress, and unemployment). In addition, potential moderating factors (demographic characteristics, individual differences, and organizational norms) are examined given the likelihood that COVID-19 will generate disparate effects. This broad-scope overview provides an integrative approach for considering the implications of COVID-19 for work, workers, and organizations while also identifying issues for future research and insights to inform solutions. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Semantics and analysis of business process models in BPMN

Abstract: The Business Process Modelling Notation (BPMN) is a standard for capturing business processes in the early phases of systems development. The mix of constructs found in BPMN makes it possible to create models with semantic errors. Such errors are especially serious, because errors in the early phases of systems development are among the most costly and hardest to correct. The ability to statically check the semantic correctness of models is thus a desirable feature for modelling tools based on BPMN. Accordingly, this paper proposes a mapping from BPMN to a formal language, namely Petri nets, for which efficient analysis techniques are available. The proposed mapping has been implemented as a tool that, in conjunction with existing Petri net-based tools, enables the static analysis of BPMN models. The formalisation also led to the identification of deficiencies in the BPMN standard specification.

Explaining the user experience of recommender systems

Abstract: Research on recommender systems typically focuses on the accuracy of prediction algorithms. Because accuracy only partially constitutes the user experience of a recommender system, this paper proposes a framework that takes a user-centric approach to recommender system evaluation. The framework links objective system aspects to objective user behavior through a series of perceptual and evaluative constructs (called subjective system aspects and experience, respectively). Furthermore, it incorporates the influence of personal and situational characteristics on the user experience. This paper reviews how current literature maps to the framework and identifies several gaps in existing work. Consequently, the framework is validated with four field trials and two controlled experiments and analyzed using Structural Equation Modeling. The results of these studies show that subjective system aspects and experience variables are invaluable in explaining why and how the user experience of recommender systems comes about. In all studies we observe that perceptions of recommendation quality and/or variety are important mediators in predicting the effects of objective system aspects on the three components of user experience: process (e.g. perceived effort, difficulty), system (e.g. perceived system effectiveness) and outcome (e.g. choice satisfaction). Furthermore, we find that these subjective aspects have strong and sometimes interesting behavioral correlates (e.g. reduced browsing indicates higher system effectiveness). They also show several tradeoffs between system aspects and personal and situational characteristics (e.g. the amount of preference feedback users provide is a tradeoff between perceived system usefulness and privacy concerns). These results, as well as the validated framework itself, provide a platform for future research on the user-centric evaluation of recommender systems.