Showing papers by "Indian Institute of Technology, Jodhpur published in 2019"

Continuing search for new physics in b → sμμ decays: two operators at a time

Abstract: The anomalies in the measurements of observables involving b → sμμ decays, namely RK, RK*, P 5 ′ , and B , may be addressed by adding lepton-universality-violating new physics contributions to the effective operators $$ {\mathcal{O}}_{\mathcal{9}},{\mathcal{O}}_{10},{\mathcal{O}}_9^{\prime },{\mathcal{O}}_{10}^{\prime } $$ . We analyze all the scenarios where the new physics contributes to a pair of these operators at a time. We perform a global fit to all relevant data in the b → s sector to estimate the corresponding new Wilson coefficients, $$ {\mathcal{O}}_9^{\mathrm{NP}},{\mathcal{O}}_{10}^{\mathrm{NP}},{\mathcal{O}}_9^{\prime },{\mathcal{O}}_{10}^{\prime } $$ . In the light of the new data on RK, and RK*, presented in Moriond 2019, we find that the scenarios with new physics contributions to the $$ \left({\mathcal{O}}_9^{\mathrm{NP}},{\mathcal{O}}_9^{\prime}\right) $$ or $$ \left({\mathcal{O}}_9^{\mathrm{NP}},{\mathcal{O}}_{10}^{\prime}\right) $$ pair remain the most favored ones. On the other hand, though the competing scenario $$ \left({\mathcal{O}}_9^{\mathrm{NP}},{\mathcal{O}}_{10}^{\mathrm{NP}}\right) $$ remains attractive, its advantage above the SM reduces significantly due to the tension that emerges between the RK and RK* measurements with the new data. The movement of the RK measurement towards unity would also result in the re-emergence of the one-parameter scenario C 9 NP = − C 9 ′ .

Continuing search for new physics in $b \to s \mu \mu$ decays: two operators at a time

Abstract: The anomalies in the measurements of observables involving $b \to s \mu\mu$ decays, namely $R_K$, $R_{K^*}$, $P_5^{\prime}$, and $B_s^\phi$, may be addressed by adding lepton-universality-violating new physics contributions to the effective operators ${\cal O}_9, {\cal O}_{10}, {\cal O}^\prime_9, {\cal O}^\prime_{10}$. We analyze all the scenarios where the new physics contributes to a pair of these operators at a time. We perform a global fit to all relevant data in the $b \to s$ sector to estimate the corresponding new Wilson coefficients, $C_9^{\rm NP}, C_{10}^{\rm NP}, C_9^\prime, C_{10}^\prime$. In the light of the new data on $R_K$ and $R_{K^*}$ presented in Moriond 2019, we find that the scenarios with new physics contributions to the ($C_9^{\rm NP}$, $C_9^\prime$) or ($C_9^{\rm NP}$, $C_{10}^\prime$) pair remain the most favored ones. On the other hand, though the competing scenario ($C_9^{\rm NP}$, $C_{10}^{\rm NP}$) remains attractive, its advantage above the SM reduces significantly due to the tension that emerges between the $R_K$ and $R_{K^*}$ measurements with the new data. The movement of the $R_K$ measurement towards unity would also result in the re-emergence of the one-parameter scenario $C_9^{\rm NP} = -C_9^\prime$.

Physical Layer Security of Hybrid Satellite-FSO Cooperative Systems

Abstract: In this paper, we study the physical layer secrecy performance of a hybrid satellite and free-space optical (FSO) cooperative system. The satellite links are assumed to follow the shadowed-Rician fading distribution, and the channel of the terrestrial link between the relay and destination is assumed to experience the gamma-gamma fading. For the FSO communications, the effects of different types of detection techniques (i.e., heterodyne detection and intensity modulation with direct detection) as well as the pointing error are considered. We derive exact analytical expressions for the average secrecy capacity and secrecy outage probability (SOP) for both cases of amplify-and-forward (AF) and decode-and-forward (DF) relaying. The asymptotic analysis for the SOP is also conducted to provide more insights on the impact of FSO and satellite channels on secrecy performance. It is found that with the AF with fixed gain scheme, the secrecy diversity order of the investigated system is only dependent on the channel characteristics of the FSO link and the FSO detection type, whereas the secrecy diversity is zero when the relay node employs DF or AF with variable-gain schemes.

Part I: Physical Insight Into Carbon-Doping-Induced Delayed Avalanche Action in GaN Buffer in AlGaN/GaN HEMTs

Abstract: Physics behind the improvement in breakdown voltage of AlGaN/GaN HEMTs with carbon-doping of GaN buffer is discussed. Modeling of carbon as acceptor traps and self-compensating acceptor/donor traps is discussed with respect to their impact on avalanche breakdown. Impact of carbon behaving as a donor as well as acceptor traps on electric field relaxation and avalanche generation is discussed in detail to establish the true nature of carbon in GaN that delays the avalanche action. This understanding of the behavior of carbon-doping in GaN buffer is then utilized to discuss design parameters related to carbon doped buffer. Design parameters such as undoped channel thickness and relative trap concentration induced by carbon-doping are discussed with respect to the performance metrics of breakdown voltage, leakage current, sheet charge density, and dynamic ON-resistance.

Late stage functionalization of heterocycles using hypervalent iodine(III) reagents

Abstract: Late stage functionalization (LSF) through direct X-H manipulations (X = C, N) enables synthetic chemists to accelerate the diversification of natural products, agrochemicals and pharmaceuticals allowing rapid access to novel bioactive molecules without resorting to arduous de novo synthesis. LSF does not only allow tapping of the hitherto unexplored chemical space but also renders the synthetic sequence more straightforward, atom economical and cost-effective. In this regard, the recent decade has witnessed the emergence of hypervalent iodine(iii) reagents as a powerful synthetic tool owing to their easy availability, mild reaction conditions, remarkable oxidizing properties and high functional group tolerance. Iodine(iii) reagents have tremendous applications in the regio- and chemo-selective late-stage functionalization of a diverse variety of heterocycles through an exciting range of transformations, such as oxidative amination, cross-dehydrogenative coupling (CDC), fluoroalkylation, azidation, halogenation and oxidation. The present review, classified according to the types of synthetic methods involved, encompasses all these recent developments in the field of transition-metal-free iodine(iii)-catalyzed/mediated direct functionalizations of heterocycles with representative examples and insightful mechanistic discussions.

Graphene Oxide–Silver Nanowire Nanocompositesfor Enhanced Sensing of Hg 2+

Abstract: We demonstrate a highly sensitive and selective sensing platform for the electrochemical detection of Hg2+ in aqueous media. A graphene oxide (GO) and silver nanowire (AgNW) nanocomposites modified...

Strain induced valley degeneracy: a route to the enhancement of thermoelectric properties of monolayer WS2

Abstract: Two-dimensional transition metal dichalcogenides show great potential as promising thermoelectric materials due to their lower dimensionality, the unique density of states and quantum confinement of carriers. Here the effects of mechanical strain on the thermoelectric performances of monolayer WS2 have been investigated using density functional theory associated with semiclassical Boltzmann transport theory. The variation of the Seebeck coefficient and band gap with applied strain has followed the same type of trend. For n-type material the relaxation time scaled power factor (S2σ/τ) increases by the application of compressive strain whereas for p-type material it increases with the application of tensile strain due to valley degeneracy. A 77% increase in the power factor has been observed for the n-type material by the application of uniaxial compressive strain. A decrease in lattice thermal conductivity with the increase in temperature causes an almost 40% increase in ZT product under applied uniaxial compressive strain. From the study, it is observed that uniaxial compressive strain is more effective among all types of strain to enhance the thermoelectric performance of monolayer WS2. Such strain induced enhancement of thermoelectric properties in monolayer WS2 could open a new window for the fabrication of high-quality thermoelectric devices.

Solution-Processed Organic Field-Effect Transistors with High Performance and Stability on Paper Substrates.

Abstract: High-performance operationally stable organic field-effect transistors were successfully fabricated on a PowerCoat HD 230 paper substrate with a TIPS-pentacene:polystyrene blend as the active layer and poly(4-vinylphenol)/HfO2 as the hybrid gate dielectric. The fabricated devices exhibited excellent p-channel characteristics with a maximum and av field effect mobility of 0.44 and 0.22(±0.11) cm2 V–1 s–1, respectively, av threshold voltage of 0.021(±0.63) V, and current on–off ratio of ∼105 while operating at −10 V. These devices exhibited remarkable stability under effects of gate bias stress and large number of repeated transfer scans with negligible performance spread. In addition, these devices displayed very stable electrical characteristics after long exposure periods to humidity and an excellent shelf life of more than 6 months in ambient environment. Thermal stress at high temperatures however deteriorates the device characteristics because of the generation and propagation of cracks in the active ...

Emerging role of circulating microRNA in the diagnosis of human infectious diseases

Abstract: The endogenic microRNAs (miRNA) are evolutionary, conserved, and belong to a group of small noncoding RNAs with a stretch of 19-24 nucleotides. The miRNAs play an indispensable role in gene modulation at the posttranscriptional level, inclusive of stem-cell differentiation, embryogenesis, hematopoiesis, metabolism, immune responses, or infections. The miRNAs secreted from the cells and their presence in the biological fluids signifies the regulatory role of circulating miRNAs in the pathogenesis. The phenomenal expression levels of circulating miRNAs in serum or plasma during infection makes them the potential therapeutic biomarkers for the diagnosis of assorted human infectious diseases. In this article, we have accentuated the methods for the profiling of circulating miRNA as well as the importance of miRNA as biomarkers for the diagnosis of human infectious diseases. To date, numerous biomarkers have been identified for the diagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection. Nevertheless, the noninvasive diagnostic approach, with the aid of biomarkers, currently plays a decisive role in the untimely diagnosis of human infections. So, in the near future, the exploitation of circulating miRNAs as therapeutic biomarkers for the diagnosis of human infections will help us to cure the associated diseases promptly and effectively.

A high-performance hydrogen sensor based on a reverse-biased MoS 2/GaN heterojunction

Abstract: We report a MoS2/GaN heterojunction-based gas sensor by depositing MoS2 over a GaN substrate via a highly controllable and scalable sputtering technique coupled with a post sulfurization process in a sulfur-rich environment. The microscopic and spectroscopic measurements expose the presence of highly crystalline and homogenous few atomic layer MoS2 on top of molecular beam epitaxially grown GaN film. Upon hydrogen exposure, the molecular adsorption tuned the barrier height at the MoS2/GaN interface under the reverse biased condition, thus resulting in high sensitivity. Our results reveal that temperature strongly affects the sensitivity of the device and it increases from 21% to 157% for 1% hydrogen with an increase in temperature (25-150 °C). For a deeper understanding of carrier dynamics at the heterointerface, we visualized the band alignment across the MoS2/GaN heterojunction having valence band and conduction band offset values of 1.75 and 0.28 eV. The sensing mechanism was demonstrated based on an energy band diagram at the MoS2/GaN interface in the presence and absence of hydrogen exposure. The proposed methodology can be readily applied to other combinations of heterostructures for sensing different gas analytes.

Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation.

Abstract: Major neurodegenerative disorders are characterized by the formation of misfolded proteins aggregates inside or outside the neuronal cells. Previous studies suggest that aberrant proteins aggregates play a critical role in protein homeostasis imbalance and failure of protein quality control (PQC) mechanism, leading to disease conditions. However, we still do not understand the precise mechanisms of PQC failure and cellular dysfunctions associated with neurodegenerative diseases caused by the accumulation of protein aggregates. Here, we show that Myricetin, a flavonoid, can eliminate various abnormal proteins from the cellular environment via modulating endogenous levels of Hsp70 chaperone and quality control (QC)-E3 ubiquitin ligase E6-AP. We have observed that Myricetin treatment suppresses the aggregation of different aberrant proteins. Myricetin also enhances the elimination of various toxic neurodegenerative diseases associated proteins from the cells, which could be reversed by the addition of putative proteasome inhibitor (MG132). Remarkably, Myricetin can also stabilize E6-AP and reduce the misfolded proteins inclusions, which further alleviates cytotoxicity. Taken together these findings suggested that new mechanistic and therapeutic insights based on small molecules mediated regulation of disturbed protein quality control mechanism, which may result in the maintenance of the state of proteostasis.

Star-Shaped ESIPT-Active Mechanoresponsive Luminescent AIEgen and Its On–Off–On Emissive Response to Cu2+/S2–

Abstract: Design and development of multifunctional materials have drawn incredible attraction in recent years. Herein, we report the design and construction of versatile star-shaped intramolecular charge transfer (ICT)-coupled excited-state intramolecular proton transfer (ESIPT)-active mechanoresponsive and aggregation-induced emissive (AIE) luminogen triaminoguanidine-diethylaminophenol (LH3 ) conjugate from simple precursors triaminoguanidine hydrochloride and 4-(N,N-diethylamino)salicylaldehyde. Solvent-dependent dual emission in nonpolar to polar protic solvents implies the presence of ICT-coupled ESIPT features in the excited state. Aggregation-enhanced emissive feature of LH3 was established in the CH3CN/water mixture. Furthermore, this compound exhibits mechanochromic fluorescence behavior upon external grinding. Fluorescence microscopy images of pristine, crystal, and crushed crystals confirm the naked-eye mechanoresponsive characteristics of LH3 . In addition, LH3 selectively sensed a Cu2+ ion through a colorimetric and fluorescence "turn-off" route, and subsequently, the LH3 -Cu2+ ensemble could act as a selective and sensitive sensor for S2- in a "turn-on" fluorescence manner via a metal displacement approach. Reversible "turn-off-turn-on" features of LH3 with Cu2+/S2- ions were efficiently demonstrated to construct the IMPLICATION logic gate function. The Cu2+/S2--responsive sensing behavior of LH3 was established in the paper strip experiment also, which can easily be characterized by the naked eye under daylight as well as a UV lamp (λ = 365 nm).

Quantum Zeno effect and nonclassicality in a PT -symmetric system of coupled cavities

Abstract: The interplay between the nonclassical features and the parity-time ($\mathcal{PT}$) symmetry (or its breaking) is studied here by considering a $\mathcal{PT}$-symmetric system consisting of two cavities with gain and loss. The conditions for $\mathcal{PT}$ invariance are obtained for this system. The behavior of the average photon number corresponding to the gain and loss modes for different initial states (e.g., vacuum, NOON, coherent, and thermal states) has also been obtained. With the help of the number operators, quantum Zeno and anti-Zeno effects are studied, and the observed behavior is compared in $\mathcal{PT}$-symmetric (PTS) and $\mathcal{PT}$-symmetry-broken (PTSB) regimes. It has been observed that the relative phase of the input coherent fields plays a key role in the occurrence of these effects. Further, some nonclassicality features are witnessed using criteria based on the number operator(s). Specifically, intermodal antibunching, sum, and difference squeezing are investigated for specific input states. It is found that the various nonclassical features, including the observed quantum Zeno and anti-Zeno effects, are suppressed when one goes from the PTS to PTSB regime. In other words, the dominance of the loss or gain rate in the field modes over the coupling strength between them diminishes the nonclassical features of the system.

Leggett-Garg inequality in the context of three flavor neutrino oscillation

Abstract: The present work is devoted to the characterization of the Leggett-Garg inequality (LGI) for three flavored neutrino oscillations in the presence of both matter and charge-conjugation and parity violating effects. This study complements and completes the recent one put forward in arXiv:1710.05562 by relaxing the stationary condition. At variance with the latter case, the LGI contains interference terms which cannot be expressed in terms of experimentally measurable quantities, thus drawing a clear-cut distinction between the two scenarios, as well as highlighting the role of the stationary assumption on such systems. We find that the additional terms are small for a high energy neutrino beam compared to the maximum value attained by the Leggett-Garg parameter.

Blind Signal PSK/QAM Recognition Using Clustering Analysis of Constellation Signature in Flat Fading Channel

Abstract: A novel method based on constellation structure is proposed to identify PSK and QAM modulation of different orders, in the slow and flat fading channel. The proposed method does not require training for threshold optimization and considers carrier frequency, symbol rate, and phase offset unknown. The symbol rate is estimated using the spectrum of the instantaneous phase of the complex baseband signal. Carrier frequency offset (CFO) is estimated and corrected from the downconverted signal and downsampled to the estimated symbol rate for extraction of constellation points. The phase offset is determined based on the symmetrical structure of constellation. The features extracted using k-medoids are used for classification of the final modulation scheme. Results show that the proposed algorithm outperforms some existing classifiers and offers lower computational complexity compared to algorithms based on subtractive clustering.

Part II: Proposals to Independently Engineer Donor and Acceptor Trap Concentrations in GaN Buffer for Ultrahigh Breakdown AlGaN/GaN HEMTs

Abstract: In part I of this paper, we developed physical insights into the role and impact of acceptor and donor traps—resulting from C-doping in GaN buffer—on avalanche breakdown in AlGaN/GaN HEMT devices. It was found that the donor traps are mandatory to explain the breakdown voltage improvement. In this paper, silicon doping is proposed and explored as an alternative to independently engineer donor trap concentration and profile. Keeping in mind the acceptor and donor trap relative concentration requirement for achieving higher breakdown buffer, as depicted in part I of this paper, silicon & carbon codoping of GaN buffer is proposed and explored in this paper. The proposed improvement in breakdown voltage is supported by physical insight into the avalanche phenomena and role of acceptor/donor traps. GaN buffer design parameters and their impact on breakdown voltage as well as leakage current are presented. Finally, a modified Si-doping profile in the GaN buffer is proposed to lower the C-doping concentration near GaN channel to mitigate the adverse effects of acceptor traps in GaN buffer.

Unusual confinement properties of a water insoluble small peptide hydrogel

Abstract: Unlike polymeric hydrogels, in the case of supramolecular hydrogels, the cross-linked network formation is governed by non-covalent forces. Hence, in these cases, the gelator molecules inside the network retain their characteristic physicochemical properties as no covalent modification is involved. Supramolecular hydrogels thus get dissolved easily in aqueous medium as the dissolution leads to a gain in entropy. Thus, any supramolecular hydrogel, insoluble in bulk water, is beyond the present understanding and hitherto not reported as well. Herein, we present a peptide-based (PyKC) hydrogel which remained insoluble in water for more than a year. Moreover, in the gel state, any movement of solvent or solute to and from the hydrogel is highly restricted resulting in a high degree of compartmentalization. The hydrogel could be re-dissolved in the presence of some biomolecules which makes it a prospective material for in vivo applications. Experimental studies and all atom molecular dynamics simulations revealed that a cysteine containing gelator forms dimers through disulfide linkage which self-assemble into PyKC layers with a distinct PyKC–water interface. The hydrogel is stabilized by intra-molecular hydrogen bonds within the peptide-conjugates and the π–π stacking of the pyrene rings. The unique confinement ability of the hydrogel is attributed to the slow dynamics of water which remains confined in the core region of PyKCvia hydrogen bonds. The hydrogen bonds present in the confined water need activation energies to move through the water depleted hydrophobic environment of pyrene rings which significantly reduces water transport across the hydrogel. The compartmentalizing ability is effectively used to protect enzymes for a long time from denaturing agents like urea, heat or methanol. Overall, the presented system shows unique insolubility and confinement properties that could be a milestone in the research of soft-materials.

A 0D Lead-Free Hybrid Crystal with Ultralow Thermal Conductivity

Abstract: Organic–inorganic hybrid materials are of significant interest owing to their diverse applications ranging from photovoltaics and electronics to catalysis. Control over the organic and inorganic components offers flexibility through tuning their chemical and physical properties. Herein, it is reported that a new organic–inorganic hybrid, [Mn(C2H6OS)6]I4, with linear tetraiodide anions exhibit an ultralow thermal conductivity of 0.15 ± 0.01 W m−1 K−1 at room temperature, which is among the lowest values reported for organic– inorganic hybrid materials. Interestingly, the hybrid compound has a unique 0D structure, which extends into 3D supramolecular frameworks through nonclassical hydrogen bonding. Phonon band structure calculations reveal that low group velocities and localization of vibrational energy underlie the observed ultralow thermal conductivity, which could serve as a general principle to design novel thermal management materials.

Self-Assembly of Artificial Sweetener Aspartame Yields Amyloid-like Cytotoxic Nanostructures.

Abstract: Recent reports have revealed the intrinsic propensity of single aromatic metabolites to undergo self-assembly and form nanostructures of amyloid nature. Hence, identifying whether aspartame, a universally consumed artificial sweetener, is inherently aggregation prone becomes an important area of investigation. Although the reports on aspartame-linked side effects describe a multitude of metabolic disorders, the mechanistic understanding of such destructive effects is largely mysterious. Since aromaticity, an aggregation-promoting factor, is intrinsic to aspartame's chemistry, it is important to know whether aspartame can undergo self-association and if such a property can predispose any cytotoxicity to biological systems. Our study finds that aspartame molecules, under mimicked physiological conditions, undergo a spontaneous self-assembly process yielding regular β-sheet-like cytotoxic nanofibrils of amyloid nature. The resultant aspartame fibrils were found to trigger amyloid cross-seeding and become a toxic aggregation trap for globular proteins, Aβ peptides, and aromatic metabolites that convert native structures to β-sheet-like fibrils. Aspartame fibrils were also found to induce hemolysis, causing DNA damage resulting in both apoptosis and necrosis-mediated cell death. Specific spatial arrangement between aspartame molecules is predicted to form a regular amyloid-like architecture with a sticky exterior that is capable of promoting viable H-bonds, electrostatic interactions, and hydrophobic contacts with biomolecules, leading to the onset of protein aggregation and cell death. Results reveal that the aspartame molecule is inherently amyloidogenic, and the self-assembly of aspartame becomes a toxic trap for proteins and cells, exposing the bitter side of such a ubiquitously used artificial sweetener.

Strain-driven thermodynamic stability and electronic transitions in ZnX (X = O, S, Se, and Te) monolayers

Abstract: Semiconducting Zn chalcogenide monolayers are important members of the 2D family of materials due to their unique electronic properties. In this paper, we focus on strain-modulated electronic properties of monolayers of ZnX, with X being O, S, Se, and Te. ZnO and ZnS monolayers have a hexagonal graphene-like planar structure, while ZnSe and ZnTe monolayers exhibit slightly buckled silicene and germanene-like structures, respectively. Density functional theory calculations find the hexagonal ZnO monolayer to be dynamically stable. However, ZnS, ZnSe, and ZnTe monolayers are predicted to be less stable with small imaginary frequencies. The application of tensile strain to these monolayers, interestingly, yields stability of dynamically less stable structures together with the modification in the nature of the bandgap from direct to indirect. For a tensile strain of about 8%, a closure of the bandgap in ZnTe is predicted with the semiconductor-metal transition. The results, therefore, find strain-induced stability and modification in electronic properties of monolayers of Zn chalcogenides, suggesting the use of these monolayers for novel device applications.