Institution
Oswaldo Cruz Foundation
Facility•Rio de Janeiro, Brazil•
About: Oswaldo Cruz Foundation is a facility organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Trypanosoma cruzi. The organization has 18673 authors who have published 36752 publications receiving 802378 citations. The organization is also known as: Fundação Oswaldo Cruz & FIOCRUZ.
Topics: Population, Trypanosoma cruzi, Immune system, Public health, Health care
Papers published on a yearly basis
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TL;DR: In vitro tests showed that the material is non-cytotoxic or genotoxic, and BC/SF:50% scaffolds configured an excellent option in bioengineering depicting its potential for tissue regeneration and cultivation of cells on nanocomposites.
179 citations
TL;DR: Findings indicate that rLipL32 may be an useful antigen for the serodiagnosis of leptospirosis, an emerging zoonosis with worldwide distribution.
Abstract: There is an urgent need for development of new serodiagnostic strategies for leptospirosis, an emerging zoonosis with worldwide distribution. We have evaluated the diagnostic utility of five recombinant antigens in enzyme-linked immunosorbent assays (ELISAs) for serodiagnosis of leptospirosis. Sera from 50 healthy residents of a high-incidence region were used to determine cutoff values for 96% specificity. In paired sera from 50 cases of leptospirosis confirmed by the microscopic agglutination test, immunoglobulin G (IgG) but not IgM reacted with the recombinant leptospiral proteins. The recombinant LipL32 IgG ELISA had the highest sensitivities in the acute (56%) and convalescent (94%) phases of leptospirosis. ELISAs based on recombinant OmpL1, LipL41, and Hsp58 had sensitivities of 16, 24, and 18% during the acute phase and 72, 44, and 32% during convalescence, respectively. Compared to sera from healthy individuals, patient sera did not react significantly with recombinant LipL36 (P > 0.05). Recombinant LipL32 IgG ELISA demonstrated 95% specificity among 100 healthy individuals, and specificities ranging from 90 to 97% among 30 dengue patients, 30 hepatitis patients, and 16 patients with diseases initially thought to be leptospirosis. Among 39 Venereal Disease Research Laboratory test-positive individuals and 30 Lyme disease patients, 13 and 23% of sera, respectively, reacted positively with the rLipL32 antigen. These findings indicate that rLipL32 may be an useful antigen for the serodiagnosis of leptospirosis.
179 citations
TL;DR: It is shown that a commonly used generic antidepressant bupropion profoundly lowers levels of TNF, interferon-gamma, and interleukin-1 beta in vivo, in a mouse lipopolysaccharide (LPS) induced inflammation model and believes a new chapter in antiinflammatory, TNF lowering treatment of disease has been opened.
179 citations
TL;DR: This review will discuss studies investigating the activity of these natural products and their derivatives in the context of the search for alternative drugs for Chagas disease, caused by Trypanosoma cruzi, a neglected illness that is endemic in Latin America.
Abstract: Naphthoquinones are compounds present in several families of higher plants. Their molecular structures confer redox properties, and they are involved in multiple biological oxidative processes. In folk medicine, especially among Indian populations, plants containing naphthoquinones have been employed for the treatment of various diseases. The biological redox cycle of quinones can be initiated by one electron reduction leading to the formation of semiquinones, unstable intermediates that react rapidly with molecular oxygen, generating free radicals. Alternatively, the reduction by two electrons, mediated by DT-diphorase, leads to the formation of hydroquinone. Lapachol, alpha-lapachone and beta-lapachone, which are isolated from the heartwood of trees of the Bignoniaceae family, are examples of bioactive naphthoquinones. In this review, we will discuss studies investigating the activity of these natural products and their derivatives in the context of the search for alternative drugs for Chagas disease, caused by Trypanosoma cruzi, a neglected illness that is endemic in Latin America.
179 citations
University of California, Los Angeles1, National Institutes of Health2, Oswaldo Cruz Foundation3, University of the Witwatersrand4, Stellenbosch University5, Universidade Federal de Minas Gerais6, University of São Paulo7, Federal University of São Paulo8, Westat9, University of California, Davis10, Boston University11, Kennedy Krieger Institute12
TL;DR: In neonates whose mothers did not receive antenatal antiretroviral therapy during pregnancy, prophylaxis with a two- or three-drug ART regimen is superior to zidovudine alone for the prevention of intrapartum HIV transmission; the two-drug regimen has less toxicity than the three- drug regimen.
Abstract: The Eunice Kennedy Shriver National Institute of Child Health and Human Development [NICHD] and others
178 citations
Authors
Showing all 18833 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Douglas T. Golenbock | 123 | 317 | 61267 |
| Guy A. Zimmerman | 109 | 328 | 39740 |
| David Brown | 105 | 1257 | 46827 |
| Liam Smeeth | 104 | 753 | 53433 |
| Ann M. Dvorak | 99 | 437 | 41073 |
| David C. Spray | 95 | 400 | 28732 |
| Theodore A. Slotkin | 89 | 575 | 30070 |
| Fernando Q. Cunha | 88 | 682 | 31501 |
| Mauro M. Teixeira | 86 | 713 | 31301 |
| Ricardo T. Gazzinelli | 86 | 340 | 28233 |
| Peter F. Weller | 85 | 331 | 22005 |
| João B. Calixto | 81 | 460 | 23029 |
| Frederic J. Seidler | 80 | 372 | 19564 |
| João Santana da Silva | 80 | 399 | 19060 |
| Deborah Carvalho Malta | 77 | 706 | 61000 |