Institution
Oswaldo Cruz Foundation
Facility•Rio de Janeiro, Brazil•
About: Oswaldo Cruz Foundation is a facility organization based out in Rio de Janeiro, Brazil. It is known for research contribution in the topics: Population & Trypanosoma cruzi. The organization has 18673 authors who have published 36752 publications receiving 802378 citations. The organization is also known as: Fundação Oswaldo Cruz & FIOCRUZ.
Topics: Population, Trypanosoma cruzi, Immune system, Public health, Health care
Papers published on a yearly basis
Papers
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TL;DR: The results show that self-rated health among older adults is multidimensional in structure, being influenced by socioeconomic conditions, social support, health status (with emphasis on mental health), and access to/use of healthcare services.
Abstract: OBJETIVO: Determinar os fatores associados a auto-avaliacao da saude entre idosos, considerando-se cinco dimensoes: sociodemografica, suporte social, habitos de vida relacionados a saude, condicoes de saude e acesso e uso de servicos de saude. METODOS: Dos 1.742 idosos (>60 anos) residentes na cidade de Bambui (Minas Gerais), 1.516 (87,0%) participaram do estudo. As informacoes foram obtidas por meio de entrevistas, exames fisicos e laboratoriais. RESULTADOS: A auto-avaliacao da saude como boa/muito boa, razoavel e ruim/muito ruim foi relatada, respectivamente, por 24,7%, 49,2% e 26,1% dos participantes. As seguintes caracteristicas apresentaram associacoes independentes e positivas com pior percepcao da saude: suporte social (insatisfacao com os relacionamentos pessoais e menor frequencia a clubes ou associacoes), condicoes de saude (sintomas depressivos/ansiosos nas ultimas duas semanas, queixa de insonia nos ultimos 30 dias, maior numero de medicamentos prescritos usados nos ultimos 30 dias) e acesso/uso de servicos de saude (queixas quando necessita de servicos medicos, maior numero de consultas medicas nos ultimos 12 meses e maior numero de internacoes hospitalares no periodo). Associacao negativa e independente foi encontrada para renda domiciliar mensal ( 4 salarios-minimos). CONCLUSOES: Os resultados mostraram uma estrutura multidimensional da auto-avaliacao da saude em idosos, compreendendo a situacao socioeconomica, suporte social, condicoes de saude (destacando-se a saude mental) e acesso e uso de servicos de saude.
148 citations
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Mario Negri Institute for Pharmacological Research1, International Agency for Research on Cancer2, Universidade Federal do Rio Grande do Sul3, National Institutes of Health4, Oswaldo Cruz Foundation5, Pennsylvania State University6, University of Lausanne7, University of Buenos Aires8, Universidade Federal de Pelotas9, University of São Paulo10, University of North Carolina at Chapel Hill11, Russian Academy12, University of Texas MD Anderson Cancer Center13, Nofer Institute of Occupational Medicine14, Curie Institute15, University of California, Los Angeles16, University of Milan17
TL;DR: In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.
Abstract: Alcohol and tobacco consumption are well-recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual-level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC (OR=1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR=2.2, 95% CI 1.6-3.1) rather than a parent (OR=1.5, 95% CI 1.1-1.8) and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, in subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR=1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR=1.3, 95% CI 1.1-1.5). No association was observed for family history of nontobacco-related neoplasms and the risk of HNC (OR=1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.
148 citations
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TL;DR: Moreira et al. as discussed by the authors studied the prevalence of sexual problems and associated help-seeking patterns among mature adults in Korea and compared the results with those obtained in other Southeast Asian and East Asian countries.
148 citations
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TL;DR: The results suggest that low power laser irradiation possibly exerts its anti-inflammatory effects by stimulating the release of adrenal corticosteroid hormones.
Abstract: The purpose of the present study was to investigate the effect of the low power laser therapy on the acute inflammatory process. Male Wistar rats were used. The rat paw oedema was induced by sub-plantar injection of carrageenan, the paw volume was measured before and 1, 2, 3 and 4 h after the injection using a hydroplethysmometer. To investigate the mechanism action of the Ga-Al-As laser on inflammatory oedema, parallel studies were performed using adrenallectomized rats or rats treated with sodium diclofenac. Different laser irradiation protocols were employed for specific energy densities (EDs), exposure times and repetition rates. The rats were irradiated with the Ga-Al-As laser during 80 s each hour. The ED that produced an anti-inflammatory effect were 1 and 2.5 J/cm(2), reducing the oedema by 27% (P<0.05) and 45.4% (P<0.01), respectively. The ED of 2.5 J/cm(2) produced anti-inflammatory effects similar to those produced by the cyclooxigenase inhibitor sodium diclofenac at a dose of 1 mg/kg. In adrenalectomized animals, the laser irradiation failed to inhibit the oedema. Our results suggest that low power laser irradiation possibly exerts its anti-inflammatory effects by stimulating the release of adrenal corticosteroid hormones.
148 citations
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TL;DR: This experimental design methodology allowed the development of an adequate process condition to attain high levels (250 mg/L) of soluble expression of functional rPly in E. coli, which should contribute to reduce operational costs.
Abstract: Streptococcus pneumoniae (S. pneumoniae) causes several serious diseases including pneumonia, septicemia and meningitis. The World Health Organization estimates that streptococcal pneumonia is the cause of approximately 1.9 million deaths of children under five years of age each year. The large number of serotypes underlying the disease spectrum, which would be reflected in the high production cost of a commercial vaccine effective to protect against all of them and the higher level of amino acid sequence conservation as compared to polysaccharide structure, has prompted us to attempt to use conserved proteins for the development of a simpler vaccine. One of the most prominent proteins is pneumolysin (Ply), present in almost all the serotypes known at the moment, which shows an effective protection against S. pneumoniae infections. We have cloned the pneumolysin gene from S. pneumoniae serotype 14 and studied the effects of eight variables related to medium composition and induction conditions on the soluble expression of rPly in Escherichia coli (E. coli) and a 28-4 factorial design was applied. Statistical analysis was carried out to compare the conditions used to evaluate the expression of soluble pneumolysin; rPly activity was evaluated by hemolytic activity assay and served as the main response to evaluate the proper protein expression and folding. The optimized conditions, validated by the use of triplicates, include growth until an absorbance of 0.8 (measured at 600 nm) with 0.1 mM IPTG during 4 h at 25°C in a 5 g/L yeast extract, 5 g/L tryptone, 10 g/L NaCl, 1 g/L glucose medium, with addition of 30 μg/mL kanamycin. This experimental design methodology allowed the development of an adequate process condition to attain high levels (250 mg/L) of soluble expression of functional rPly in E. coli, which should contribute to reduce operational costs. It was possible to recover the protein in its active form with 75% homogeneity.
148 citations
Authors
Showing all 18833 results
Name | H-index | Papers | Citations |
---|---|---|---|
Douglas T. Golenbock | 123 | 317 | 61267 |
Guy A. Zimmerman | 109 | 328 | 39740 |
David Brown | 105 | 1257 | 46827 |
Liam Smeeth | 104 | 753 | 53433 |
Ann M. Dvorak | 99 | 437 | 41073 |
David C. Spray | 95 | 400 | 28732 |
Theodore A. Slotkin | 89 | 575 | 30070 |
Fernando Q. Cunha | 88 | 682 | 31501 |
Mauro M. Teixeira | 86 | 713 | 31301 |
Ricardo T. Gazzinelli | 86 | 340 | 28233 |
Peter F. Weller | 85 | 331 | 22005 |
João B. Calixto | 81 | 460 | 23029 |
Frederic J. Seidler | 80 | 372 | 19564 |
João Santana da Silva | 80 | 399 | 19060 |
Deborah Carvalho Malta | 77 | 706 | 61000 |