Shanghai Jiao Tong University

About: Shanghai Jiao Tong University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Population & Cancer. The organization has 157524 authors who have published 184620 publications receiving 3451038 citations. The organization is also known as: Shanghai Communications University & Shanghai Jiaotong University.

Zeta potential : a surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells

Abstract: We demonstrate the use of surface Zeta potential measurements as a new tool to investigate the interactions of iron oxide nanoparticles and cowpea mosaic virus (CPMV) nanoparticles with human normal breast epithelial cells (MCF10A) and cancer breast epithelial cells (MCF7) respectively. A substantial understanding in the interaction of nanoparticles with normal and cancer cells in vitro will enable the capabilities of improving diagnostic and treatment methods in cancer research, such as imaging and targeted drug delivery. A theoretical Zeta potential model is first established to show the effects of binding process and internalization process during the nanoparticle uptake by cells and the possible trends of Zeta potential change is predicted for different cell endocytosis capacities. The corresponding changes of total surface charge of cells in the form of Zeta potential measurements were then reported after incubated respectively with iron oxide nanoparticles and CPMV nanoparticles. As observed, after MCF7 and MCF10A cells were incubated respectively with two types of nanoparticles, the significant differences in their surface charge change indicate the potential role of Zeta potential as a valuable biological signature in studying the cellular interaction of nanoparticles, as well as specific cell functionality.

Dispersing Carbon Nanotubes with Graphene Oxide in Water and Synergistic Effects between Graphene Derivatives

Abstract: (Figure Presented) Synergistic graphenes: The chemical and electrical synergies between graphene derivatives enable a simple, cost-effective and environmentally friendly strategy for solution-phase processing of graphene oxide (GO) and carbon nanotubes (CNTs). The new nanohybrid exhibits high performance when used as electrodes for supercapacitors (see figure; ER=electrochemically reduced, CCG = chemically converted graphene). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Online Multi-Object Tracking with Dual Matching Attention Networks

Abstract: In this paper, we propose an online Multi-Object Tracking (MOT) approach which integrates the merits of single object tracking and data association methods in a unified framework to handle noisy detections and frequent interactions between targets. Specifically, for applying single object tracking in MOT, we introduce a cost-sensitive tracking loss based on the state-of-the-art visual tracker, which encourages the model to focus on hard negative distractors during online learning. For data association, we propose Dual Matching Attention Networks (DMAN) with both spatial and temporal attention mechanisms. The spatial attention module generates dual attention maps which enable the network to focus on the matching patterns of the input image pair, while the temporal attention module adaptively allocates different levels of attention to different samples in the tracklet to suppress noisy observations. Experimental results on the MOT benchmark datasets show that the proposed algorithm performs favorably against both online and offline trackers in terms of identity-preserving metrics.

Antibody-Drug Conjugates: A Comprehensive Review

Abstract: Antibody-drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that directed toward a target antigen expressed on the cancer cell surface, reducing systemic exposure and therefore toxicity. ADCs are complex molecules that require careful attention to various components. Selection of an appropriate target, an mAb, cytotoxic payload, and the manner in which the antibody is linked to the payload are key determinants of the safety and efficacy of ADCs. This review provides an overview of the systemic evaluation of each component of an ADC design, improved understanding of the mechanism of action of ADC, and mechanistic pathways involved in ADC resistance and various strategies to optimize ADC design. Moreover, this review also shed light on the current status of ADCs that have gained regulatory approval from the FDA including a description of biology and chemistry, metabolic profiles, adverse events, drug interactions, and the future perspective on combination strategies with other agents, including immunotherapy.