Shanghai Jiao Tong University

About: Shanghai Jiao Tong University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Population & Cancer. The organization has 157524 authors who have published 184620 publications receiving 3451038 citations. The organization is also known as: Shanghai Communications University & Shanghai Jiaotong University.

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Abstract: Extracellular vesicles such as exosomes and microvesicles (MVs) are shed by cancer cells, are detected in the plasma of cancer patients, and promote cancer progression, but the molecular mechanisms regulating their production are not well understood. Intratumoral hypoxia is common in advanced breast cancers and is associated with an increased risk of metastasis and patient mortality that is mediated in part by the activation of hypoxia-inducible factors (HIFs). In this paper, we report that exposure of human breast cancer cells to hypoxia augments MV shedding that is mediated by the HIF-dependent expression of the small GTPase RAB22A, which colocalizes with budding MVs at the cell surface. Incubation of naive breast cancer cells with MVs shed by hypoxic breast cancer cells promotes focal adhesion formation, invasion, and metastasis. In breast cancer patients, RAB22A mRNA overexpression in the primary tumor is associated with decreased overall and metastasis-free survival and, in an orthotopic mouse model, RAB22A knockdown impairs breast cancer metastasis.

Robust Stability and Stabilization of Fractional-Order Interval Systems with the Fractional Order $\alpha$ : The $0≪\alpha≪1$ Case

Abstract: This technical note firstly presents a sufficient and necessary condition for the robust asymptotical stability of fractional-order interval systems with the fractional order α satisfying 0 < α < 1. And then a sufficient condition for the robust asymptotical stabilization of such fractional-order interval systems is derived. All the results are obtained in terms of linear matrix inequalities. Finally, two illustrative examples are given to show that our results are effective for checking the robust stability and designing the robust stabilizing controller for fractional-order interval systems.