University of Haifa

About: University of Haifa is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 7558 authors who have published 27141 publications receiving 711629 citations. The organization is also known as: Haifa University & Universiṭat Ḥefah.

p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs

Abstract: Large parts of mammalian genomes are transcriptionally inactive and enriched with various classes of interspersed and tandem repeats. Here we show that the tumor suppressor protein p53 cooperates with DNA methylation to maintain silencing of a large portion of the mouse genome. Massive transcription of major classes of short, interspersed nuclear elements (SINEs) B1 and B2, both strands of near-centromeric satellite DNAs consisting of tandem repeats, and multiple species of noncoding RNAs was observed in p53-deficient but not in p53 wild-type mouse fibroblasts treated with the DNA demethylating agent 5-aza-2’-deoxycytidine. The abundance of these transcripts exceeded the level of β-actin mRNA by more than 150-fold. Accumulation of these transcripts, which are capable of forming double-stranded RNA (dsRNA), was accompanied by a strong, endogenous, apoptosis-inducing type I IFN response. This phenomenon, which we named “TRAIN” (for “transcription of repeats activates interferon”), was observed in spontaneous tumors in two models of cancer-prone mice, presumably reflecting naturally occurring DNA hypomethylation and p53 inactivation in cancer. These observations suggest that p53 and IFN cooperate to prevent accumulation of cells with activated repeats and provide a plausible explanation for the deregulation of IFN function frequently seen in tumors. Overall, this work reveals roles for p53 and IFN that are key for genetic stability and therefore relevant to both tumorigenesis and the evolution of species.

Thinking, Walking, Talking: Integratory Motor and Cognitive Brain Function.

Abstract: In this article, we argue that motor and cognitive processes are functionally related and most likely share a similar evolutionary history. This is supported by clinical and neural data showing that some brain regions integrate both motor and cognitive functions. In addition, we also argue that cognitive processes coincide with complex motor output. Further, we also review data that support the converse notion that motor processes can contribute to cognitive function, as found by many rehabilitation and aerobic exercise training programs. Support is provided for motor and cognitive processes possessing dynamic bidirectional influences on each other.

The Treaty of Nice and qualified majority voting

Abstract: We analyse and evaluate three decision rules for the Council of Ministers of the EU, which are prescribed by the `definitive form' of the Treaty of Nice. The first will apply from 2005 to the present 15-member EU, if it will not have been enlarged by then. The second or third will apply to an enlarged 27-member EU. We conclude that the first of these is an improvement on the current decision rule; but the other two have extremely undesirable features.

Transformational leadership and attachment.

Abstract: Attachment theory posits that the child's experiences with attachment figures (mostly parents) form the basis for an internal working model of self and others that can be either secure (others and self are perceived positively) or insecure (others or self are perceived negatively). In adulthood, these models are reflected in attachment styles which are manifested in various realms (e.g., romantic relationships). This article expands the conceptualization derived from attachment theory to the area of leadership. The arguments presented are anchored in the similarity found in the literature between characteristics of the secure attachment style and those of transformational leaders. The central hypothesis is that the style of transformational leadership will correlate positively with the secure attachment style. This hypothesis was examined in three studies conducted in officers' courses, using different sources of report in each study. In all three studies, significant correlations were found between secure attachment and transformational leadership. This new direction of research has important implications for the understanding of the personality and development processes of transformational leaders.

Coalition formation with uncertain heterogeneous information

Abstract: Coalition formation methods allow agents to join together and are thus necessary in cases where tasks can only be performed cooperatively by groups. This is the case in the Request For Proposal (RFP) domain, where some requester business agent issues an RFP - a complex task comprised of sub-tasks - and several service provider agents need to join together to address this RFP. In such environments the value of the RFP may be common knowledge, however the costs that an agent incurs for performing a specific sub-task are unknown to other agents. Additionally, time for addressing RFPs is limited. These constraints make it hard to apply traditional coalition formation mechanisms, since those assume complete information, and time constraints are of lesser significance there.To address this problem, we have developed a protocol that enables agents to negotiate and form coalitions, and provide them with simple heuristics for choosing coalition partners. The protocol and the heuristics allow the agents to form coalitions in the face of time constraints and incomplete information. The overall payoff of agents using our heuristics is very close to an experimentally measured optimal value, as our extensive experimental evaluation shows.