Institution
University of Haifa
Education•Haifa, Israel•
About: University of Haifa is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 7558 authors who have published 27141 publications receiving 711629 citations. The organization is also known as: Haifa University & Universiṭat Ḥefah.
Topics: Population, Poison control, Context (language use), Politics, Anxiety
Papers published on a yearly basis
Papers
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TL;DR: The present review analyzes the pecularities of polysaccharides derived from fruiting bodies and cultured mycelium in selected examples of medicinal mushrooms and concludes that high molecular weight glucans appear to be more effective than those of low molecular weight.
Abstract: The number of mushrooms on Earth is estimated at 140,000, yet maybe only 10% (approximately 14,000 named species) are known. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of polysaccharides with antitumor and immunostimulating properties. Many, if not all, Basidiomycetes mushrooms contain biologically active polysaccharides in fruit bodies, cultured mycelium, culture broth. Data on mushroom polysaccharides have been collected from 651 species and 7 infraspecific taxa from 182 genera of higher Hetero- and Homobasidiomycetes. These polysaccharides are of different chemical composition, with most belonging to the group of β-glucans; these have β-(1→3) linkages in the main chain of the glucan and additional β-(1→6) branch points that are needed for their antitumor action. High molecular weight glucans appear to be more effective than those of low molecular weight. Chemical modification is often carried out to improve the antitumor activity of polysaccharides and their clinical qualities (mostly water solubility). The main procedures used for chemical improvement are: Smith degradation (oxydo-reducto-hydrolysis), formolysis, and carboxymethylation. Most of the clinical evidence for antitumor activity comes from the commercial polysaccharides lentinan, PSK (krestin), and schizophyllan, but polysaccharides of some other promising medicinal mushroom species also show good results. Their activity is especially beneficial in clinics when used in conjunction with chemotherapy. Mushroom polysaccharides prevent oncogenesis, show direct antitumor activity against various allogeneic and syngeneic tumors, and prevent tumor metastasis. Polysaccharides from mushrooms do not attack cancer cells directly, but produce their antitumor effects by activating different immune responses in the host. The antitumor action of polysaccharides requires an intact T-cell component; their activity is mediated through a thymus-dependent immune mechanism. Practical application is dependent not only on biological properties, but also on biotechnological availability. The present review analyzes the pecularities of polysaccharides derived from fruiting bodies and cultured mycelium (the two main methods of biotechnological production today) in selected examples of medicinal mushrooms.
1,962 citations
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TL;DR: This paper compares several estimation procedures for the Youden Index and its associated cutoff point and finds that the empirical method which is the most commonly used has the overall worst performance.
Abstract: The Youden Index is a frequently used summary measure of the ROC (Receiver Operating Characteristic) curve. It both, measures the effectiveness of a diagnostic marker and enables the selection of an optimal threshold value (cutoff point) for the marker. In this paper we compare several estimation procedures for the Youden Index and its associated cutoff point. These are based on (1) normal assumptions; (2) transformations to normality; (3) the empirical distribution function; (4) kernel smoothing. These are compared in terms of bias and root mean square error in a large variety of scenarios by means of an extensive simulation study. We find that the empirical method which is the most commonly used has the overall worst performance. In the estimation of the Youden Index the kernel is generally the best unless the data can be well transformed to achieve normality whereas in estimation of the optimal threshold value results are more variable.
1,760 citations
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University of Sydney1, University Hospitals Birmingham NHS Foundation Trust2, Newcastle upon Tyne Hospitals NHS Foundation Trust3, Spanish National Research Council4, University of Haifa5, The Chinese University of Hong Kong6, University of Bern7, University of Mainz8, Kurume University9, Pontifical Catholic University of Chile10, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico11, Mansoura University12, Minerva Foundation Institute for Medical Research13, Shanghai Jiao Tong University14, Aarhus University Hospital15, Marmara University16, University of Lisbon17, University of São Paulo18, Paris Diderot University19, University of Western Australia20, First Affiliated Hospital of Wenzhou Medical University21, Minia University22, University of Malaya23, National Autonomous University of Mexico24, Yonsei University25, University of Paris26, University of Turin27
TL;DR: A panel of international experts from 22 countries propose a new definition of metabolic-dysfunction-associated fatty liver disease that is both comprehensive yet simple for the diagnosis of MAFLD and is independent of other liver diseases.
1,705 citations
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17 Jun 2006TL;DR: A novel algorithm for tracking an object in a video sequence represented by multiple image fragments or patches, which is able to handle partial occlusions or pose change and overcomes several difficulties which cannot be handled by traditional histogram-based algorithms.
Abstract: We present a novel algorithm (which we call "Frag- Track") for tracking an object in a video sequence. The template object is represented by multiple image fragments or patches. The patches are arbitrary and are not based on an object model (in contrast with traditional use of modelbased parts e.g. limbs and torso in human tracking). Every patch votes on the possible positions and scales of the object in the current frame, by comparing its histogram with the corresponding image patch histogram. We then minimize a robust statistic in order to combine the vote maps of the multiple patches. A key tool enabling the application of our algorithm to tracking is the integral histogram data structure [18]. Its use allows to extract histograms of multiple rectangular regions in the image in a very efficient manner. Our algorithm overcomes several difficulties which cannot be handled by traditional histogram-based algorithms [8, 6]. First, by robustly combining multiple patch votes, we are able to handle partial occlusions or pose change. Second, the geometric relations between the template patches allow us to take into account the spatial distribution of the pixel intensities - information which is lost in traditional histogram-based algorithms. Third, as noted by [18], tracking large targets has the same computational cost as tracking small targets. We present extensive experimental results on challenging sequences, which demonstrate the robust tracking achieved by our algorithm (even with the use of only gray-scale (noncolor) information).
1,522 citations
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Kansas State University1, University of Bristol2, United States Department of Agriculture3, University of Bologna4, Consiglio per la ricerca e la sperimentazione in agricoltura5, Norwegian University of Life Sciences6, University of Adelaide7, Murdoch University8, University of Haifa9, Bayer10, Blaise Pascal University11, University of Udine12, University of Saskatchewan13, University of California, Berkeley14, Howard Hughes Medical Institute15, Illumina16
TL;DR: The developed array and cluster identification algorithms provide an opportunity to infer detailed haplotype structure in polyploid wheat and will serve as an invaluable resource for diversity studies and investigating the genetic basis of trait variation in wheat.
Abstract: High-density single nucleotide polymorphism (SNP) genotyping arrays are a powerful tool for studying genomic patterns of diversity, inferring ancestral relationships between individuals in populations and studying marker-trait associations in mapping experiments. We developed a genotyping array including about 90,000 gene-associated SNPs and used it to characterize genetic variation in allohexaploid and allotetraploid wheat populations. The array includes a significant fraction of common genome-wide distributed SNPs that are represented in populations of diverse geographical origin. We used density-based spatial clustering algorithms to enable high-throughput genotype calling in complex data sets obtained for polyploid wheat. We show that these model-free clustering algorithms provide accurate genotype calling in the presence of multiple clusters including clusters with low signal intensity resulting from significant sequence divergence at the target SNP site or gene deletions. Assays that detect low-intensity clusters can provide insight into the distribution of presence-absence variation (PAV) in wheat populations. A total of 46 977 SNPs from the wheat 90K array were genetically mapped using a combination of eight mapping populations. The developed array and cluster identification algorithms provide an opportunity to infer detailed haplotype structure in polyploid wheat and will serve as an invaluable resource for diversity studies and investigating the genetic basis of trait variation in wheat.
1,451 citations
Authors
Showing all 7747 results
Name | H-index | Papers | Citations |
---|---|---|---|
Markku Laakso | 162 | 945 | 142292 |
M.-Marsel Mesulam | 150 | 558 | 90772 |
Michael Levin | 111 | 986 | 45667 |
Peter Schmidt | 105 | 638 | 61822 |
Eviatar Nevo | 95 | 848 | 40066 |
Uri Alon | 91 | 442 | 54822 |
Dan Roth | 85 | 523 | 28166 |
Simon G. Potts | 82 | 249 | 31557 |
Russell G. Foster | 79 | 318 | 23206 |
Leo Radom | 79 | 604 | 34075 |
Stevan E. Hobfoll | 74 | 271 | 35870 |
Larry Davidson | 69 | 459 | 20177 |
Alan R. Templeton | 67 | 249 | 28320 |
Uri Gneezy | 65 | 211 | 29671 |
Benny Pinkas | 64 | 156 | 21122 |