Institution
University of Madras
Education•Chennai, Tamil Nadu, India•
About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.
Papers published on a yearly basis
Papers
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TL;DR: A better index of protein hydrophobicity is introduced, showing very good correlation with the extent to which residues are buried5 compared with the hydrophobic indices used previously, and it could be used to characterise tertiary structures.
Abstract: PREDICTIVE studies on the secondary structure of globular proteins aimed at locating ordered structural segments have provided little information about spatial orientations or even as to whether residues are exposed or buried. However, the physico-chemical properties1 of residues can be used to obtain such information. In particular the hydrophobic character2, is a useful parameter in these studies. The hydrophobic character as defined by the indices given by Tanford3 and Jones4 does not reflect hydrophobic environment within protein structures, but we introduce here a new parameter, the ‘bulk hydrophobic character’ obtained from an analysis of the surrounding hydrophobic environment of amino acid residues in protein crystals. This is a better index of protein hydrophobicity, showing very good correlation with the extent to which residues are buried5 (correlation coefficient r = 0.9) compared with the hydrophobic indices used previously, and it could be used to characterise tertiary structures.
282 citations
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TL;DR: In this article, a simple and green method for the synthesis of l-tyrosine-stabilized silver and gold nanoparticles in aqueous medium under ambient sunlight irradiation was reported.
Abstract: In this study, we report a simple and green method for the synthesis of l-tyrosine-stabilized silver (AgNPs) and gold nanoparticles (AuNPs) in aqueous medium under ambient sunlight irradiation. The nanoparticles (NPs) are characterized by UV–visible spectroscopy, high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy (FT-IR), cyclic voltammetry (CV), and dynamic light scattering (DLS) techniques. The size and shape of the metal NPs could be controlled by changing the concentration of the substrate, metal precursors, and pH of the medium. The synthesized AgNPs are found to be highly sensitive to Hg2+ and Mn2+ ions with the detection limit for both ions as low as 16 nM under optimized conditions. However AuNPs are found to be sensitive to Hg2+ and Pb2+ ions with a detection limit as low as 53 and 16 nM, respectively. The proposed method was found to be useful for colorimetric detection of heavy metal ions in aqueous medium.
282 citations
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TL;DR: Andrographolide from Andrographis paniculata is evaluated as a potential inhibitor of the main protease of SARS-COV-2 (Mpro) through in silico studies such as molecular docking, target analysis, toxicity prediction and ADME prediction and Computational approaches predicts this molecule to have good solubility, pharmacodynamics property and target accuracy.
Abstract: SARS-CoV-2 virus which caused the global pandemic the Coronavirus Disease- 2019 (COVID-2019) has infected about 1,203,959 patients and brought forth death rate about 64,788 among 206 countries as m...
275 citations
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TL;DR: These biologically synthesized nanoparticles were proved to exhibit excellent cytotoxic effect on HeLa cell and the X-ray diffraction spectrum XRD pattern clearly indicates that the silver nanoparticles formed in the present synthesis were crystalline in nature.
270 citations
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TL;DR: In vitro antibacterial activities of drugs capped Au nanoparticles (Au@drugs) were investigated and suggest that gold nanoparticles could act as an effective drug carrier in drug delivery system.
268 citations
Authors
Showing all 8535 results
Name | H-index | Papers | Citations |
---|---|---|---|
David A. Kass | 127 | 580 | 58747 |
Viswanathan Mohan | 110 | 964 | 64896 |
Sridevi Devaraj | 85 | 365 | 21831 |
Raghavan Srinivasan | 80 | 959 | 37821 |
Muthupandian Ashokkumar | 76 | 511 | 20771 |
K.V. Rajagopalan | 71 | 223 | 15129 |
Rajasekhar Balasubramanian | 65 | 276 | 13854 |
Savarimuthu Ignacimuthu | 64 | 498 | 17752 |
Pappannan Thiyagarajan | 59 | 245 | 10650 |
Ravi Subrahmanyan | 59 | 353 | 14244 |
Fritz Scholz | 55 | 385 | 11420 |
M. Lakshmanan | 54 | 533 | 13357 |
Nagarajan Selvamurugan | 52 | 153 | 9477 |
Kumarasamy Thangaraj | 47 | 361 | 11869 |
Suniti Solomon | 46 | 191 | 6400 |