University of Madras

About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.

α-MoO3/polyaniline composite for effective scavenging of Rhodamine B, Congo red and textile dye effluent

Abstract: Polyaniline modified MoO3 composites were synthesized via a chemical oxidative polymerization method and employed as a novel adsorbent for Rhodamine B (RhB), Congo red (CR) and textile dye effluent. In this preparation, camphor-10-sulphonic acid was used as a dopant and ammonium peroxydisulphate was used as an oxidant for the fabrication of polyaniline. The MoO3/polyaniline composites were characterized by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), UV-Vis spectroscopy and elemental analysis. The results confirm the successful formation of the MoO3/polyaniline composite. The surface morphology of the samples was characterized by scanning electron microscopy and transmission electron microscopy. The obtained images show the formation of polyaniline-coated MoO3. The adsorption performance of the prepared composites towards RhB and CR was analyzed. The effect of pH on adsorptive removal was investigated. The adsorption isotherm studies were carried out and the results showed that the equilibrium data fitted well to the Langmuir isotherm equation. The MoO3/polyaniline (aniline, 30% w/w) composite shows better scavenging performance with maximum adsorption capacity of 36.36 mg g−1 and 76.22 mg g−1 on RhB and CR dyes from water. In addition, the adsorptive performance on real textile effluent was also tested. The results show that the MoO3/polyaniline composite can be used as a cost-effective alternative adsorbent for the removal of organic pollutants from waste water.

Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent against prostate cancer in an in vivo model by inhibiting the EGFR signaling pathway.

Abstract: Prostate cancer incidence and mortality rates have increased over the past years. The purpose of the present study was to examine the molecular mechanism underlying the chemopreventive effects of quercetin on prostate cancer in an in vivo model. Sprague-Dawley male rats were divided into four groups, Group I: vehicle control (propylene glycol), Group II: chemically induced cancer model (MNU + T); Group III: chemically induced cancer model + quercetin (200 mg per kg b.w.); Group IV: quercetin (200 mg per kg b.w.). Serum levels of quercetin were assessed by high performance liquid chromatography (HPLC). EGFR, PI3K/Akt protein levels were significantly increased in chemically induced cancer rats, which were brought back to normalcy in both DLP & VP (dorsolateral prostate & ventral prostate) by quercetin supplementation. Also, the protein expression levels of proliferating cell nuclear antigen (PCNA), N-cadherin, vimentin, and cyclin D1 exhibited a significant increase in both DLP & VP of chemically induced cancer rats. However, simultaneous quercetin supplementation significantly decreased PCNA, N-cadherin, vimentin, and cyclin D1 protein levels compared to chemically induced cancer rats. The E-cadherin expression was decreased in chemically induced cancer animals. Simultaneous quercetin supplementation prevented it. Real time PCR was used to study the mRNA expression of snail, slug and twist. Quercetin significantly decreased snail, slug, and twist mRNA levels in chemically induced cancer rats. To conclude from the present study, quercetin was effective in preventing prostate cancer progression by inhibiting the EGFR signaling pathway and by regulating cell adhesion molecules in Sprague Dawley rats.