Institution
University of Madras
Education•Chennai, Tamil Nadu, India•
About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.
Papers published on a yearly basis
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TL;DR: The findings indicate that MUC1 CT plays a role in the intracellular signaling through its interaction with β‐catenin and upregulate the Wnt target gene cyclinD1 in CagA H. pylori‐infected gastric carcinoma.
Abstract: Beta-catenin can function as an oncogene when it is translocated to the nucleus, binds to T-cell factor (TCF) or lymphoid enhance factor and transactivate its target gene. The mechanism responsible for the activation of Wnt signaling pathway in the Cytotoxin-associated antigen A (CagA) Helicobacter pylori (H. pylori)-infected gastric carcinoma has not been elucidated. We hypothesize that whether interaction of MUC1 with beta-catenin modulates the Wnt signaling and its target gene cyclinD1 in CagA H. pylori-infected gastric carcinoma. The result demonstrate that binding of MUC1 CT with Protein Kinase C delta (PKC delta), tyrosine phosphorylation of MUC1 CT, and CagA are strongly associated with the interaction of MUC1 with beta-catenin in CagA H. pylori-infected gastric carcinoma. A statistically significant difference (chi(2) = 24.49; P < 0.001) was found when the binding of MUC1 CT and beta-catenin was compared to subcellular localization of beta-catenin. We also observed significant statistical correlation (chi(2) = 14.885; P < 0.001) between the cyclinD1 overexpression and the subcellular localization of beta-catenin. The overexpression of cyclinD1 was significantly higher (chi(2) = 13.785; P < 0.002) in advanced gastric carcinoma with CagA H. pylori infection. In addition cyclinD1 overexpression was significantly higher (chi(2) = 37.267; P < 0.001) with the interaction of MUC1 CT with beta-catenin in advanced gastric cancer. These findings indicate that MUC1 CT plays a role in the intracellular signaling through its interaction with beta-catenin and upregulate the Wnt target gene cyclinD1 in CagA H. pylori-infected gastric carcinoma.
66 citations
TL;DR: Results reveal that Amrita Bindu, a salt-spice-herbal mixture exerts a promising antioxidant potential against free radical induced oxidative damage.
66 citations
TL;DR: It was found that nHAp nanocomposites improved the proliferation on Saos-2 osteoblast-like cell lines and the microwave-assisted synthesis and characterization of n HAp (nano-hydroxyapatite)-alumina composites was reported.
66 citations
TL;DR: Morphological observation by phase contrast microscopy revealed that both crocetin and quercetin caused intense damage only on the malignant (RD) cells, whereas mild toxic effect was seen with cisplatin also on normal (Vero) cells.
66 citations
TL;DR: In this article, 4,6-Diaryl-prop-2-en-1-ones 1a-k and malononitrile by a convenient one-pot method were synthesized from 1,3-diarylprop2-2.1-one-ones.
66 citations
Authors
Showing all 8535 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| David A. Kass | 127 | 580 | 58747 |
| Viswanathan Mohan | 110 | 964 | 64896 |
| Sridevi Devaraj | 85 | 365 | 21831 |
| Raghavan Srinivasan | 80 | 959 | 37821 |
| Muthupandian Ashokkumar | 76 | 511 | 20771 |
| K.V. Rajagopalan | 71 | 223 | 15129 |
| Rajasekhar Balasubramanian | 65 | 276 | 13854 |
| Savarimuthu Ignacimuthu | 64 | 498 | 17752 |
| Pappannan Thiyagarajan | 59 | 245 | 10650 |
| Ravi Subrahmanyan | 59 | 353 | 14244 |
| Fritz Scholz | 55 | 385 | 11420 |
| M. Lakshmanan | 54 | 533 | 13357 |
| Nagarajan Selvamurugan | 52 | 153 | 9477 |
| Kumarasamy Thangaraj | 47 | 361 | 11869 |
| Suniti Solomon | 46 | 191 | 6400 |