Institution
University of Madras
Education•Chennai, Tamil Nadu, India•
About: University of Madras is a education organization based out in Chennai, Tamil Nadu, India. It is known for research contribution in the topics: Ring (chemistry) & Lipid peroxidation. The organization has 8496 authors who have published 11369 publications receiving 211152 citations. The organization is also known as: Madras University & University of Chennai.
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TL;DR: It is shown that tangeretin significantly suppresses DMBA induced breast cancer in rats, and the histological and ultrastructural analysis of breast tissues evidenced the anti-tumorigenic nature of tange retin.
61 citations
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TL;DR: In this paper, a series of unsymmetrical macrocyclic binuclear bis-phenoxo bridged oxidovanadium(IV) complexes have been synthesized and characterized by elemental and spectral techniques.
61 citations
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TL;DR: Acyclic dicompartmental ligands suitable for the complexation of transition-metal ions which can form mononuclear, homo- or heterodinuclear complexes have been synthesized.
61 citations
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TL;DR: It was shown that phycocyanin was able to markedly inhibit the growth of drug resistant bacteria Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa andStaphylococcus aureus while, no activity was recorded in Acinetobacter baumanii and Enterococcus durans.
Abstract: The experimental data on the study of the antibacterial activity of purified phycocyanin, a protein-bound pigment isolated from blue-green alga, Spirulina platensis (Nordstedt) Geitler, Oscillatoriaceae are generalized and it was shown that phycocyanin was able to markedly inhibit the growth of drug resistant bacteria Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa andStaphylococcus aureus while, no activity was recorded in Acinetobacter baumanii and Enterococcus durans, this is the first report of the activity of purified C-phycocyanin against drug resistant bacteria. The possible use of phycocyanin as a drug with associated antibacterial activity is discussed.
61 citations
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TL;DR: Investigation of the chemotherapeutic effect of tangeretin against 7,12-dimethylbenz(α)anthracene (DMBA)-induced rat mammary carcinogenesis and its underlying mechanism of action provides new evidence on the mechanism of Action, and extends the hypothesis supporting its potential use in chemotherapy.
Abstract: Breast cancer is the most commonly diagnosed cancer among women worldwide, which is characterized by unregulated cell growth and metastasis. Many bioactive compounds of plant origin such as tangeretin have been shown to possess potent antioxidant and anticancerous properties. In the present study we have investigated the chemotherapeutic effect of tangeretin against 7,12-dimethylbenz(α)anthracene (DMBA)-induced rat mammary carcinogenesis and studied its underlying mechanism of action. Breast cancer was induced by “air pouch technique” with a single dose of 25mg/kg of DMBA. Tangeretin (50 mg/kg) was administered orally for four weeks. Remarkably, tangeretin treatment controlled the growth of cancer cells which was clearly evidenced by morphological and histological analysis. Also, serum levels of estradiol, progesterone and prolactin; lipid bound sialic acid and total sialic acid and the tissue levels of nitric oxide and protein carbonyls of cancer induced animals were decreased upon tangeretin treatment. Staining of breast tissues for nucleolar organizer regions, mast cells, glycoproteins, lipids and collagen showed that tangeretin treatment to breast cancer induced rats significantly reduced tumorigenesis. Oral tangeretin treatment also effectively reduced the tumor cell proliferation markers such as PCNA, COX-2 and Ki-67. Further, tangeretin treatment arrested the cancer cell division at the G1/S phase via p53/p21 up-regulation and inhibited metastasis by suppressing matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor. Taken together, the data provides new evidence on the mechanism of action of tangeretin in breast cancer and hence extends the hypothesis supporting its potential use in chemotherapy.
61 citations
Authors
Showing all 8535 results
Name | H-index | Papers | Citations |
---|---|---|---|
David A. Kass | 127 | 580 | 58747 |
Viswanathan Mohan | 110 | 964 | 64896 |
Sridevi Devaraj | 85 | 365 | 21831 |
Raghavan Srinivasan | 80 | 959 | 37821 |
Muthupandian Ashokkumar | 76 | 511 | 20771 |
K.V. Rajagopalan | 71 | 223 | 15129 |
Rajasekhar Balasubramanian | 65 | 276 | 13854 |
Savarimuthu Ignacimuthu | 64 | 498 | 17752 |
Pappannan Thiyagarajan | 59 | 245 | 10650 |
Ravi Subrahmanyan | 59 | 353 | 14244 |
Fritz Scholz | 55 | 385 | 11420 |
M. Lakshmanan | 54 | 533 | 13357 |
Nagarajan Selvamurugan | 52 | 153 | 9477 |
Kumarasamy Thangaraj | 47 | 361 | 11869 |
Suniti Solomon | 46 | 191 | 6400 |