Institution
University of Utah
Education•Salt Lake City, Utah, United States•
About: University of Utah is a education organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 52894 authors who have published 124076 publications receiving 5265834 citations. The organization is also known as: The U & The University of Utah.
Topics: Population, Medicine, Poison control, Health care, Cancer
Papers published on a yearly basis
Papers
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Foothills Medical Centre1, University of Calgary2, Ghent University Hospital3, McMaster University4, Fremantle Hospital5, Tulane University6, Uppsala University7, University of Helsinki8, Loma Linda University9, University College Hospital10, Orlando Regional Medical Center11, VCU Medical Center12, University of Tartu13, University of Western Australia14, University of Notre Dame15, John Hunter Hospital16, Liverpool Hospital17, Albert Einstein Medical Center18, University of Utah19, Universidad Anáhuac México Norte20
TL;DR: The overall quality of evidence available to guide development of RECOMMENDATIONS was generally low and Appropriately designed intervention trials are urgently needed for patients with IAH and ACS.
Abstract: Purpose
To update the World Society of the Abdominal Compartment Syndrome (WSACS) consensus definitions and management statements relating to intra-abdominal hypertension (IAH) and the abdominal compartment syndrome (ACS).
1,100 citations
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Johns Hopkins University1, University of Utah2, Stanford University3, American Society of Clinical Oncology4, Ontario Institute for Cancer Research5, University of Sydney6, University of Nottingham7, St. Jude Medical Center8, University of Toronto9, Mayo Clinic10, University of Southern California11, Indiana University12, National Institutes of Health13, The Royal Marsden NHS Foundation Trust14
TL;DR: The HER2 testing algorithm for breast cancer is updated and requires concomitant IHC review for dual-probe ISH groups 2 to 4 to arrive at the most accurate HER2 status designation (positive or negative) based on combined interpretation of the ISH and IHC assays.
Abstract: Purpose To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists human epidermal growth factor receptor 2 (HER2) testing in breast cancer guideline. Methods Based on the signals approach, an Expert Panel reviewed published literature and research survey results on the observed frequency of less common in situ hybridization (ISH) patterns to update the recommendations. Recommendations Two recommendations addressed via correspondence in 2015 are included. First, immunohistochemistry (IHC) 2+ is defined as invasive breast cancer with weak to moderate complete membrane staining observed in > 10% of tumor cells. Second, if the initial HER2 test result in a core needle biopsy specimen of a primary breast cancer is negative, a new HER2 test may (not "must") be ordered on the excision specimen based on specific clinical criteria. The HER2 testing algorithm for breast cancer is updated to address the recommended work-up for less common clinical scenarios (approximately 5% of cases) observed when using a dual-probe ISH assay. These scenarios are described as ISH group 2 ( HER2/chromosome enumeration probe 17 [CEP17] ratio ≥ 2.0; average HER2 copy number < 4.0 signals per cell), ISH group 3 ( HER2/CEP17 ratio < 2.0; average HER2 copy number ≥ 6.0 signals per cell), and ISH group 4 ( HER2/CEP17 ratio < 2.0; average HER2 copy number ≥ 4.0 and < 6.0 signals per cell). The diagnostic approach includes more rigorous interpretation criteria for ISH and requires concomitant IHC review for dual-probe ISH groups 2 to 4 to arrive at the most accurate HER2 status designation (positive or negative) based on combined interpretation of the ISH and IHC assays. The Expert Panel recommends that laboratories using single-probe ISH assays include concomitant IHC review as part of the interpretation of all single-probe ISH assay results. Find additional information at www.asco.org/breast-cancer-guidelines .
1,100 citations
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TL;DR: The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.
Abstract: Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.
1,097 citations
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TL;DR: Dietary patterns characterized by increased dairy consumption have a strong inverse association with IRS among overweight adults and may reduce risk of type 2 diabetes and cardiovascular disease.
Abstract: ContextComponents of the insulin resistance syndrome (IRS), including obesity,
glucose intolerance, hypertension, and dyslipidemia, are major risk factors
for type 2 diabetes and heart disease. Although diet has been postulated to
influence IRS, the independent effects of dairy consumption on development
of this syndrome have not been investigated.ObjectiveTo examine associations between dairy intake and incidence of IRS, adjusting
for confounding lifestyle and dietary factors.DesignThe Coronary Artery Risk Development in Young Adults (CARDIA) study,
a population-based prospective study.Setting and ParticipantsGeneral community sample from 4 US metropolitan areas of 3157 black
and white adults aged 18 to 30 years who were followed up from 1985-1986 to
1995-1996.Main Outcome MeasureTen-year cumulative incidence of IRS and its association with dairy
consumption, measured by diet history interview.ResultsDairy consumption was inversely associated with the incidence of all
IRS components among individuals who were overweight (body mass index ≥25
kg/m2) at baseline but not among leaner individuals (body mass
index <25 kg/m2). The adjusted odds of developing IRS (2 or
more components) were 72% lower (odds ratio, 0.28; 95% confidence interval,
0.14-0.58) among overweight individuals in the highest (≥35 times per week,
24/102 individuals) compared with the lowest (<10 times per week, 85/190
individuals) category of dairy consumption. Each daily occasion of dairy consumption
was associated with a 21% lower odds of IRS (odds ratio, 0.79; 95% confidence
interval, 0.70-0.88). These associations were similar for blacks and whites
and for men and women. Other dietary factors, including macronutrients and
micronutrients, did not explain the association between dairy intake and IRS.ConclusionsDietary patterns characterized by increased dairy consumption have a
strong inverse association with IRS among overweight adults and may reduce
risk of type 2 diabetes and cardiovascular disease.
1,093 citations
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TL;DR: This hypothesis also accounts for the authors' late maturity, small size at weaning, and high fertility, and has implications for past human habitat choice and social organization and for ideas about the importance of extended learning and paternal provisioning in human evolution.
Abstract: Long postmenopausal lifespans distinguish humans from all other primates. This pattern may have evolved with mother–child food sharing, a practice that allowed aging females to enhance their daughters’ fertility, thereby increasing selection against senescence. Combined with Charnov’s dimensionless assembly rules for mammalian life histories, this hypothesis also accounts for our late maturity, small size at weaning, and high fertility. It has implications for past human habitat choice and social organization and for ideas about the importance of extended learning and paternal provisioning in human evolution.
1,093 citations
Authors
Showing all 53431 results
Name | H-index | Papers | Citations |
---|---|---|---|
Bert Vogelstein | 247 | 757 | 332094 |
George M. Whitesides | 240 | 1739 | 269833 |
Hongjie Dai | 197 | 570 | 182579 |
Robert M. Califf | 196 | 1561 | 167961 |
Frank E. Speizer | 193 | 636 | 135891 |
Yusuke Nakamura | 179 | 2076 | 160313 |
David L. Kaplan | 177 | 1944 | 146082 |
Marc G. Caron | 173 | 674 | 99802 |
George M. Church | 172 | 900 | 120514 |
Steven P. Gygi | 172 | 704 | 129173 |
Lily Yeh Jan | 162 | 467 | 73655 |
Tobin J. Marks | 159 | 1621 | 111604 |
David W. Bates | 159 | 1239 | 116698 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Charles M. Perou | 156 | 573 | 202951 |