Institution
University of Utah
Education•Salt Lake City, Utah, United States•
About: University of Utah is a education organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 52894 authors who have published 124076 publications receiving 5265834 citations. The organization is also known as: The U & The University of Utah.
Topics: Population, Medicine, Poison control, Health care, Cancer
Papers published on a yearly basis
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TL;DR: This review focuses on three well-studied sensory systems in Escherichia coli and Salmonella typhimurium to illustrate some of the design features and molecular mechanisms of bacterial signaling proteins.
752 citations
TL;DR: The HNPP locus is assigned to chromosome 17p11.2 and the presence of a large interstitial deletion associated with this disorder is demonstrated in three unrelated pedigrees, suggesting that these genetic disorders may be the result of reciprocal products of unequal crossover.
751 citations
TL;DR: The Database Consortium model is now externally validated and can be applied to stratify patients by risk in clinical trials and to counsel patients about prognosis.
Abstract: Summary Background The International Metastatic Renal-Cell Carcinoma Database Consortium model offers prognostic information for patients with metastatic renal-cell carcinoma. We tested the accuracy of the model in an external population and compared it with other prognostic models. Methods We included patients with metastatic renal-cell carcinoma who were treated with first-line VEGF-targeted treatment at 13 international cancer centres and who were registered in the Consortium's database but had not contributed to the initial development of the Consortium Database model. The primary endpoint was overall survival. We compared the Database Consortium model with the Cleveland Clinic Foundation (CCF) model, the International Kidney Cancer Working Group (IKCWG) model, the French model, and the Memorial Sloan-Kettering Cancer Center (MSKCC) model by concordance indices and other measures of model fit. Findings Overall, 1028 patients were included in this study, of whom 849 had complete data to assess the Database Consortium model. Median overall survival was 18·8 months (95% 17·6–21·4). The predefined Database Consortium risk factors (anaemia, thrombocytosis, neutrophilia, hypercalcaemia, Karnofsky performance status Interpretation The Database Consortium model is now externally validated and can be applied to stratify patients by risk in clinical trials and to counsel patients about prognosis. Funding None.
751 citations
TL;DR: The authors found that a greater degree of data-driven processing of a word, such as having a subject read the word out of context, facilitated later perceptual identification of that word and less facilitation of perceptual identification.
751 citations
TL;DR: The American College of Medical Genetics has developed the following professional guidelines for the interpretation and reporting of copy number variation: evaluation of constitutional copy number variants detected in the postnatal setting.
751 citations
Authors
Showing all 53431 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Bert Vogelstein | 247 | 757 | 332094 |
| George M. Whitesides | 240 | 1739 | 269833 |
| Hongjie Dai | 197 | 570 | 182579 |
| Robert M. Califf | 196 | 1561 | 167961 |
| Frank E. Speizer | 193 | 636 | 135891 |
| Yusuke Nakamura | 179 | 2076 | 160313 |
| David L. Kaplan | 177 | 1944 | 146082 |
| Marc G. Caron | 173 | 674 | 99802 |
| George M. Church | 172 | 900 | 120514 |
| Steven P. Gygi | 172 | 704 | 129173 |
| Lily Yeh Jan | 162 | 467 | 73655 |
| Tobin J. Marks | 159 | 1621 | 111604 |
| David W. Bates | 159 | 1239 | 116698 |
| Alfred L. Goldberg | 156 | 474 | 88296 |
| Charles M. Perou | 156 | 573 | 202951 |