University of Valencia

About: University of Valencia is a education organization based out in Valencia, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 27096 authors who have published 65669 publications receiving 1765689 citations. The organization is also known as: Universitat de València & UV.

Acute exercise activates nuclear factor (NF)-κB signaling pathway in rat skeletal muscle

Abstract: Two studies were performed to investigate the effects of an acute bout of physical exercise on the nuclear protein kappaB (NF-kappaB) signaling pathway in rat skeletal muscle. In Study 1, a group of rats (n=6) was run on the treadmill at 25 m/min, 5% grade, for 1 h or until exhaustion (Ex), and compared with a second group (n=6) injected with two doses of pyrrolidine dithiocarbamate (PDTC, 100 mg/kg, i.p.) 24 and 1 h prior to the acute exercise bout. Three additional groups of rats (n=6) were injected with either 8 mg/kg (i.p.) of lipopolysaccharide (LPS), 1 mmol/kg (i.p.) t-butylhydroperoxide (tBHP), or saline (C) and killed at resting condition. Ex rats showed higher levels of NF-kappaB binding and P50 protein content in muscle nuclear extracts compared with C rats. Cytosolic IkappaBalpha and IkappaB kinase (IKK) contents were decreased, whereas phospho-IkappaBalpha and phospho-IKK contents were increased, comparing Ex vs. C. The exercise-induced activation of NF-kappaB signaling cascade was partially abolished by PDTC treatment. LPS, but not tBHP, treatment mimicked and exaggerated the effects observed in Ex rats. In Study 2, the time course of exercise-induced NF-kappaB activation was examined. Highest levels of NF-kappaB binding were observed at 2 h postexercise. Decreased cytosolic IkappaBalpha and increased phosphor-IkappaBalpha content were found 0-1 h postexercise whereas P65 reached peak levels at 2-4 h. These data suggest that the NF-kappaB signaling pathway can be activated in a redox-sensitive manner during muscular contraction, presumably due to increased oxidant production. The cascade of intracellular events may be the overture to elevated gene expression of manganese superoxide dismutase reported earlier (Pfluegers Arch. 442, 426-434, 2001).

The genomic history of the Iberian Peninsula over the past 8000 years.

Abstract: J.M.F., F.J.L.-C., J.I.M., F.X.O., J.D., and M.S.B. were supported by HAR2017-86509-P, HAR2017-87695-P, and SGR2017-11 from the Generalitat de Catalunya, AGAUR agency. C.L.-F. was supported by Obra Social La Caixa and by FEDER-MINECO (BFU2015- 64699-P). L.B.d.L.E. was supported by REDISCO-HAR2017-88035-P (Plan Nacional I+D+I, MINECO). C.L., P.R., and C.Bl. were supported by MINECO (HAR2016-77600-P). A.Esp., J.V.-V., G.D., and D.C.S.-G. were supported by MINECO (HAR2009-10105 and HAR2013-43851-P). D.J.K. and B.J.C. were supported by NSF BCS-1460367. K.T.L., A.W., and J.M. were supported by NSF BCS-1153568. J.F.-E. and J.A.M.-A. were supported by IT622-13 Gobierno Vasco, Diputacion Foral de Alava, and Diputacion Foral de Gipuzkoa. We acknowledge support from the Portuguese Foundation for Science and Technology (PTDC/EPH-ARQ/4164/2014) and the FEDER-COMPETE 2020 project 016899. P.S. was supported by the FCT Investigator Program (IF/01641/2013), FCT IP, and ERDF (COMPETE2020 – POCI). M.Si. and K.D. were supported by a Leverhulme Trust Doctoral Scholarship awarded to M.B.R. and M.P. D.R. was supported by an Allen Discovery Center grant from the Paul Allen Foundation, NIH grant GM100233, and the Howard Hughes Medical Institute. V.V.-M. and W.H. were supported by the Max Planck Society.

Outflows from AGN: Kinematics of the Narrow-Line and Coronal-Line Regions in Seyfert Galaxies

Abstract: As part of an extensive study of the physical properties of active galactic nuclei (AGN) we report high spatial resolution near-IR integral-field spectroscopy of the narrow-line region (NLR) and coronal-line region (CLR) of seven Seyfert galaxies. These measurements elucidate for the first time the two-dimensional spatial distribution and kinematics of the recombination line Br{\gamma} and high-ionization lines [Sivi], [Alix] and [Caviii] on scales <300 pc from the AGN. The observations reveal kinematic signatures of rotation and outflow in the NLR and CLR. The spatially resolved kinematics can be modeled as a combination of an outflow bicone and a rotating disk coincident with the molecular gas. High-excitation emission is seen in both components, suggesting it is leaking out of a clumpy torus. While NGC 1068 (Seyfert 2) is viewed nearly edge-on, intermediate-type Seyferts are viewed at intermediate angles, consistent with unified schemes. A correlation between the outflow velocity and the molecular gas mass in r<30 pc indicates that the accumulation of gas around the AGN increases the collimation and velocity of the outflow. The outflow rate is 2-3 orders of magnitude greater than the accretion rate, implying that the outflow is mass-loaded by the surrounding interstellar medium (ISM). In half of the observed AGN the kinetic power of the outflow is of the order of the power required by two-stage feedback models to be thermally coupled to the ISM and match the M-{\sigma}* relation. In these objects the radio jet is clearly interacting with the ISM, indicative of a link between jet power and outflow power.

The Resource-Based Theory of the Firm and Firm Survival

Abstract: This paper examines the determinants of firm survival. We use hazard models to test a number of hypotheses mainly drawn from the Resource-Based Theory of the Firm. According to the Resource-Based View the ability of a firm to develop distinct capabilities enhances its ability to adapt to the changing competitive environment and improves its survival prospects. The results confirm that firms that develop firm-specific assets through advertising and making R&D (independently of the technological intensity of the industry) enjoy better survival prospects. Furthermore, failure risk increases up to about 20 years of trading, and then decreases to later rise in line with liability of “adolescence” and “senescence.”