University of Valencia

About: University of Valencia is a education organization based out in Valencia, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 27096 authors who have published 65669 publications receiving 1765689 citations. The organization is also known as: Universitat de València & UV.

Integrin activation by talin, kindlin and mechanical forces

Abstract: Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework. In this Perspective, Fassler and co-authors describe current models of how integrin adhesion molecules are activated and stabilised, and the importance of forces in this process.

Modelling safety climate in the prediction of levels of safety activity

Abstract: This study examined the architecture of the relationships between components of organizational safety climate, including employee attitudes to safety issues and perceptions of the work environment, and related this to self-reported levels of safety activity. Data were collected from a large multinational manufacturing organization by questionnaire. A total of 915 valid questionnaires were returned and formed the basis for structural equation modelling and subsequent analyses. These data showed that a common structure, or architecture, of attitudes to safety issues and perceptions of the work environment could be constructed that explained levels of safety activity. The strength of employees' attitudes with regard to safety management played a pivotal role in this model through both direct and indirect paths. This is consistent with earlier findings on the importance of management commitment in organizations with well developed safety cultures. An examination of the differences between plants/site...