Wilkes University

About: Wilkes University is a education organization based out in Wilkes-Barre, Pennsylvania, United States. It is known for research contribution in the topics: Population & Pharmacy. The organization has 616 authors who have published 1032 publications receiving 21050 citations. The organization is also known as: Wilkes & Wilkes College.

Facilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience.

Abstract: A hallmark of the research experience is encountering difficulty and working through those challenges to achieve success. This ability is essential to being a successful scientist, but replicating such challenges in a teaching setting can be difficult. The Genomics Education Partnership (GEP) is a consortium of faculty who engage their students in a genomics Course-Based Undergraduate Research Experience (CURE). Students participate in genome annotation, generating gene models using multiple lines of experimental evidence. Our observations suggested that the students' learning experience is continuous and recursive, frequently beginning with frustration but eventually leading to success as they come up with defendable gene models. In order to explore our "formative frustration" hypothesis, we gathered data from faculty via a survey, and from students via both a general survey and a set of student focus groups. Upon analyzing these data, we found that all three datasets mentioned frustration and struggle, as well as learning and better understanding of the scientific process. Bioinformatics projects are particularly well suited to the process of iteration and refinement because iterations can be performed quickly and are inexpensive in both time and money. Based on these findings, we suggest that a dynamic of "formative frustration" is an important aspect for a successful CURE.

Aggressive behavior in institutionalized elders: A theoretical framework:

Abstract: This review article explores current research on aggression in institutionc ized elders and proposes a theoretical framework for use by caregivers. The relationships of brain dysfunction, past beha...

Dominance of the α1B-Adrenergic Receptor and its Subcellular Localization in Human and TRAMP Prostate Cancer Cell Lines

Abstract: The function and distribution of alpha1-adrenergic receptor (AR) subtypes in prostate cancer cells is well characterized. Previous studies have used RNA localization or low-avidity antibodies in tissue or cell lines to determine the alpha1-AR subtype and suggested that the alpha1A-AR is dominant. Two androgen-insensitive, human metastatic cancer cell lines DU145 and PC3 were used as well as the mouse TRAMP C1-C3 primary and clonal cell lines. The density of alpha1-ARs was determined by saturation binding and the distribution of the different alpha1-AR subtypes was examined by competition-binding experiments. In contrast to previous studies, the major alpha1-AR subtype in DU145, PC3 and all of the TRAMP cell lines is the alpha1B-AR. DU145 cells contained 100% of the alpha1B-AR subtype, whereas PC3 cells were composed of 21% alpha1 A-AR and 79% alpha1B-AR. TRAMP cell lines contained between 66% and 79% of the alpha1B-AR with minor fractions of the other two subtypes. Faster doubling time in the TRAMP cell lines correlated with decreasing alpha 1B-AR and increasing alpha1 A- and alpha1D-AR densities. Transfection with EGFP-tagged alpha1B-ARs revealed that localization was mainly intracellular, but the majority of the receptors translocated to the cell surface after extended preincubation (18 hr) with either agonist or antagonist. Localization was confirmed by ligand-binding studies and inositol phosphate assays where prolonged preincubation with either agonist and/or antagonist increased the density and function of alpha 1-ARs, suggesting that the native receptors were mostly intracellular and nonfunctional. Our studies indicate that alpha1B-ARs are the major alpha1-AR subtype expressed in DU145, PC3, and all TRAMP cell lines, but most of the receptor is localized in intracellular compartments in a nonfunctional state, which can be rescued upon prolonged incubation with any ligand.

Policy-seeking candidates who value the valence attributes of the winner

Abstract: Several recent spatial modeling studies incorporate valence issues—e.g., voters’ evaluations of the candidates’ competence, integrity, and charisma—that may give one of the candidates an electoral advantage that is independent of his policy positions. However to date all such models assume that while voters value positive valence characteristics, the candidates themselves do not. We develop a spatial model where the candidates are valence-seeking, i.e.—like the voters—the candidates prefer that the winning candidate possess qualities, such as integrity, diligence, and competence, that will enhance his job performance. We analyze a spatial model where the candidates value both the valence qualities and the policies of the winning candidate, and we show that the candidates’ optimal policy choices typically diverge as the valence differential between them increases, and in particular that the valence-disadvantaged candidate normally has incentives to become more extreme as the valence advantage of her opponent increases.

20/sup st/ century engineer-entrepreneur

Abstract: The emerging facts from successful organizations, including universities, indicate that the real source of power in a knowledge-based economy is in combining technical prowess with entrepreneurship. This paper first highlights missing links in the aptitude and attitude of an engineer in combining technical knowledge with sound decision-making and effective entrepreneurship. Second, it discusses the gaps in traditional college education, and their remedies through outcome-based curricula. Third, it presents the distinction between leadership and management with reference to new models espoused in the theory of constraints (TOC). Fourth, it outlines the skills needed for the professional development of an individual to transform him or her from a traditional quantitative/verbal thinker to a future-oriented visionary by redirecting the whole-brain thinking. Finally, critical success factors in the development of an effective and efficient knowledge worker for the 21st century is enumerated.